Jun Zhang, Laura K. Herzog, Shuang Li, Xi Chen, Yao-Wen Wu
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引用次数: 0
Abstract
Dancing with light: A chemo-optogenetic system has been developed by using azobenzene-based photoswitchable molecular glues (sMGs) to reversibly control protein dimerization/proximity in living cells. Under blue light, these molecules bring two proteins together, whereas green light causes them to separate, like a dance. This system provides a new tool for studying complex cell processes with high precision in both time and space. More information can be found in the Research Article by Y. W. Wuand co-workers (DOI: 10.1002/chem.202403808).
与光共舞通过使用偶氮苯基光开关分子胶（sMGs）来可逆地控制活细胞中蛋白质的二聚化/接近，我们开发出了一种化学光遗传系统。在蓝光照射下，这些分子会将两个蛋白质聚集在一起，而绿光则会使它们分开，就像跳舞一样。该系统为在时间和空间上高精度地研究复杂的细胞过程提供了一种新工具。更多信息，请参阅 Y. W. Wu 及其合作者的研究文章（DOI.Wu 及其合作者的研究文章中（DOI: 10.1002/chem.202403808）。
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