Characteristics and Epidemiological Analysis of Enterococcal Infection from Beijing Teaching Hospital in China, 2010 - 2021.

Abstract

Background: The purpose of the study was to understand the distribution and drug resistance characteristics of Enterococcus so as to provide a reliable basis for clinical use of antibiotics and hospital infection control.

Methods: In total, 3,455 strains of Enterococcus, isolated from January 2010 through December 2021, were col-lected. Bruker MALDI biotyper, MICROSCAN walkaway 40 analysis system, and Vitek-2 compact automatic drug sensitivity identification analyzer were used to identify the strains and to test drug sensitivity, and then the results were analyzed. Whonet 5.6 software and SPSS 20.0 were used for data analysis.

Results: Among the 3,455 pathogens, the top three were Enterococcus faecium (1,819 strains, 52.65%), Enterococcus faecalis (1,310 strains, 37.92%), and Enterococcus gallinarum (1,203 strains, 3.47%). There were more strains from females (1,808 strains, 52.33%) than from males (1,647 strains, 47.67%). Furthermore, 1,446 strains (41.85%) were isolated from urine samples, and the resistance rates to vancomycin and linezolid were 15.72% and 0.58%, respectively. The resistance rates to penicillin, ampicillin, ciprofloxacin, and levofloxacin were higher than 50%.

Conclusions: Enterococcus faecium was the main pathogen of enterococcal infection. Most of them were cultured in urine. The multi-drug resistance was high. Vancomycin-resistant Enterococcus cannot be ignored. Bacterial resistance monitoring provides an important theoretical basis for clinicians to rationally use antibiotics and prevent nosocomial infection.