Artificial Single-Layer, Multi-Layer, and Gradient Scaffolds for Enhancing the Healing of Tendon-to-Bone Interfaces: A Mini-Review.

IF 1.7 Q2 ORTHOPEDICS Orthopedic Research and Reviews Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI:10.2147/ORR.S501260
Tianyi Song, Lin Guo, Changcheng Wang, Mingcheng Li
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引用次数: 0

Abstract

Tendon healing after ligament or tendon reconstruction remains a significant challenge. Regenerative tissue engineering, an interdisciplinary field that combines biology, materials science, and engineering, offers promising solutions. Recent developments have introduced scaffold materials designed to enhance the proliferation and differentiation of tendon-to-bone tissue cells. These scaffolds possessing three-dimensional composites of tissue cells and biomaterials, have proven effective in facilitating tendon-to-bone curing post-surgery. The successful development of the tendon-to-bone interface is a critical factor for early rehabilitation and functional recovery. In this mini-review, we present a comprehensive update on contemporary strategies for synthetic scaffold-based materials and their influence on tendon-to-bone healing. We described the synthetic materials compositions, structures and features of single-layer, multi-layer, and gradient scaffolds with their special mechanical properties. We examined the construction of engineering scaffolds from the perspectives of biomaterials and design strategies, providing a comprehensive evaluation of the advantages and disadvantages associated with each approach. Ultimately, this review articulates clear research directions aimed at achieving breakthroughs in future studies.

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来源期刊
Orthopedic Research and Reviews
Orthopedic Research and Reviews Medicine-Orthopedics and Sports Medicine
CiteScore
2.80
自引率
0.00%
发文量
51
审稿时长
16 weeks
期刊介绍: Orthopedic Research and Reviews is an international, peer-reviewed, open-access journal focusing on the patho-physiology of the musculoskeletal system, trauma, surgery and other corrective interventions to restore mobility and function. Advances in new technologies, materials, techniques and pharmacological agents will be particularly welcome. Specific topics covered in the journal include: Patho-physiology and bioengineering, Technologies and materials science, Surgical techniques, including robotics, Trauma management and care, Treatment including pharmacological and non-pharmacological, Rehabilitation and Multidisciplinarian care approaches, Patient quality of life, satisfaction and preference, Health economic evaluations. The journal welcomes submitted papers covering original research, basic science and technology, clinical studies, reviews and evaluations, guidelines, expert opinion and commentary, case reports and extended reports.
期刊最新文献
Artificial Single-Layer, Multi-Layer, and Gradient Scaffolds for Enhancing the Healing of Tendon-to-Bone Interfaces: A Mini-Review. Red Yeast Rice Increases Bone Morphogenetic Protein-2 Expression and Enhances Fracture Healing Process in Delayed Union Models of Sprague-Dawley Rats: A Preclinical Study. Anterior Knee Pain Evaluation Following Anterior Cruciate Ligament (ACL) Reconstruction Using Anterior Half of The Peroneus Longus (AHPL) Autograft. Network Pharmacology and Experimental Validation of the Therapeutic Effect of Baji Capsule on LPS-Induced Osteoporosis. Isolated Idiopathic Cervical Dystonia with a Rare Type of Atlantoaxial Dislocation. A Case Report and a Short Literature Review.
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