Prospects for Obtaining L-Methionine Using Biotechnological Methods Based on Escherichia coli and Corynebacterium glutamicum: Part 1. Application, Methods of L-Methionine Production, and Regulation of its Biosynthesis in Bacteria
V. A. Livshits, D. M. Bubnov, T. E. Shustikova, A. A. Khozov, T. E. Leonova, L. E. Ryabchenko, T. V. Vybornaya, A. A. Stepanova, A. S. Yanenko
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Abstract—In the first part of the review presented, the role of L-methionine in the vital activity of various organisms and its application are considered. The main methods of obtaining it are presented briefly. The pathways of biosynthesis of L-methionine and its precursors, as well as their regulation in industrially significant bacterial species Escherichia coli and Corynebacterium glutamicum, are described. The current information on the uptake and assimilation reduction of sulfate and thiosulfate in these bacteria as the most important elements of metabolism limiting the possibility of oversynthesis of L-methionine is presented. At the same time, some approaches used in the creation of effective producer strains for the production of L-methionine using biotechnological methods are mentioned.
期刊介绍：
Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.
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