{"title":"A Review on the Treatment and Diagnosis of Systemic Lupus Erythematosus Using Nanoparticle Systems","authors":"Amin Seddigh, Zahra Salmasi, Fatemeh Kalalinia, Somayeh Marouzi, Maryam Hashemi","doi":"10.1007/s12247-025-09954-x","DOIUrl":null,"url":null,"abstract":"<div><p>Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by inflammation due to autoantibodies against nuclear antigens. Current treatments suffer from poor bioavailability, low specificity, and significant side effects. Nanoparticle (NP)-based drug delivery systems offer promising alternatives through enhancing solubility, stability, bioavailability, controlled release and targeted delivery of drugs. Recent studies have demonstrated that NPs with various structures provide a novel approach for treating SLE, potentially reducing side effects while improving efficacy of therapeutic agents. This review aims to present the current status of SLE therapy, along with the potential advantages and challenges of using NPs in diagnosis and treatment of SLE.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Innovation","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12247-025-09954-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by inflammation due to autoantibodies against nuclear antigens. Current treatments suffer from poor bioavailability, low specificity, and significant side effects. Nanoparticle (NP)-based drug delivery systems offer promising alternatives through enhancing solubility, stability, bioavailability, controlled release and targeted delivery of drugs. Recent studies have demonstrated that NPs with various structures provide a novel approach for treating SLE, potentially reducing side effects while improving efficacy of therapeutic agents. This review aims to present the current status of SLE therapy, along with the potential advantages and challenges of using NPs in diagnosis and treatment of SLE.
期刊介绍：
The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories:
Materials science,
Product design,
Process design, optimization, automation and control,
Facilities; Information management,
Regulatory policy and strategy,
Supply chain developments ,
Education and professional development,
Journal of Pharmaceutical Innovation publishes four issues a year.
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