Associations of fundus tessellation, myopic diffuse chorioretinal atrophy and choroidal thickness with visual acuity in myopia

IF 2.8 3区医学 Q1 OPHTHALMOLOGY Acta Ophthalmologica Pub Date : 2025-03-11 DOI:10.1111/aos.17480

Jost B. Jonas, Songhomitra Panda-Jonas, Jie Xu, Wen Bin Wei, Ya Xing Wang

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Abstract

Purpose

To explore associations between stages of myopic macular degeneration (MMD) and visual acuity and influencing parameters.

Methods

Participants of the population-based study Beijing Eye Study (n = 3468 participants) underwent a detailed ocular and systemic examination.

Results

Assessable images were available for 3040 (87.7%) individuals (age: 64.0 ± 9.7 years). In multivariable analysis, worse best-corrected visual acuity (BCVA) (i.e. higher logMAR values) was associated with higher MMD stage (beta: 0.11; B: 0.06; 95% CI: 0.04, 0.08; p < 0.001) and thinner subfoveal choroidal thickness (beta: −0.06; p = 0.002), with adjustments for age, sex, educational level, cognitive function, degree of any cataract and prevalence of glaucoma, diabetic retinopathy and age-related macular degeneration. If only eyes with MMD grade 1 or no MMD were included, worse BCVA was associated (multivariable analysis) with higher prevalence of MMD stage 1 (beta: 0.11; B: 0.07; 95% CI: 0.05, 0.09; p < 0.001) and thinner medium-sized choroidal vessel layer thickness. Correspondingly, BCVA was worse in eyes with MMD stage 1 than in eyes without MMD (0.13 ± 0.27 logMAR vs. 0.04 ± 0.14; p < 0.001). Including only eyes without vision-influencing disorders (except myopia), BCVA was also worse in eyes with MMD stage 1 than in eyes without MMD (0.06 ± 0.13 logMAR vs. −0.01 ± 0.08 logMAR; p < 0.001). In these eyes without vision-influencing ocular disorders, worse BCVA was associated with thinner total subfoveal choroidal thickness (beta: −0.15; R: 0.000; 95% CI: 0.000, 0.000; p < 0.001) and longer axial length (beta: 0.14; R: 0.01; 95% CI: 0.01, 0.02; p < 0.001), or alternatively with higher MMD staging (beta: 0.24; R: 0.09; 95% CI: 0.01, 0.11; p < 0.001).

Conclusions

MMD stage 1 (fundus tessellation) is associated with decreased BCVA and may be considered pathological. Independently of longer axial length, thinner choroidal thickness is a factor associated with lower BCVA in myopic eyes, including eyes with MMD stage 1.

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近视眼眼底细纹、近视眼弥漫性脉络膜视网膜萎缩和脉络膜厚度与视力的关系。

目的：探讨近视黄斑变性（MMD）分期与视力的关系及其影响因素。方法：以人群为基础的北京眼科研究的参与者（n = 3468名参与者）接受了详细的眼部和全身检查。结果：3040例（87.7%）个体（年龄：64.0±9.7岁）可获得可评估图像。在多变量分析中，较差的最佳矫正视力（BCVA）（即较高的logMAR值）与较高的烟雾病分期相关(beta值：0.11；B: 0.06;95% ci: 0.04, 0.08；结论：MMD 1期（眼底镶嵌）与BCVA降低相关，可视为病理性。与较长的眼轴长度无关，较薄的脉络膜厚度是近视眼（包括1期烟雾病眼）BCVA较低的一个相关因素。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.