Differential Effect of Hospitalization on Cystatin C- and Creatinine-Based Estimated GFR.

IF 9.4 1区 医学 Q1 UROLOGY & NEPHROLOGY Journal of The American Society of Nephrology Pub Date : 2025-03-11 DOI:10.1681/ASN.0000000670
Ian E McCoy, Alan S Go, Jesse Y Hsu, Xiaoming Zhang, Anthony N Muiru, Vallabh O Shah, Matthew Weir, Hernan Rincon-Choles, Debbie L Cohen, Amanda Anderson, Bernard Jaar, James Sondheimer, Panduranga S Rao, Anand Srivastava, Laura M Dember, Jiang He, Jing Chen, Chi-Yuan Hsu
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住院对基于胱抑素 C 和肌酸酐的估计 GFR 的不同影响。
背景:胱抑素C已进入主流临床护理作为肾功能的测量,加入血清肌酐已使用了近一个世纪。但是许多医生注意到eGFRCr和eGFRCys的值可能有很大的不同。已知危重疾病住院可急剧降低eGFRdiff (eGFRCys - eGFRCr)。然而,这种效应是否发生在全因住院治疗中并在住院后持续存在尚不清楚。方法:在慢性肾功能不全队列(CRIC)研究的5,599名成人受试者中,研究人员测量了血清肌酐和胱抑素C,估计了每年研究访问(未住院和住院)之间六类总住院天数的相关性。与研究访视期间未住院相比,住院天数增加与eGFRCys下降相关(例如,住院≥42天,-3.30 [95% CI -5.48, -1.13] ml/min/1.73m2,趋势检验)。结论:与出院后数月测量的eGFRCr相比,延长或重复住院与更大的eGFRCys下降相关。
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来源期刊
Journal of The American Society of Nephrology
Journal of The American Society of Nephrology 医学-泌尿学与肾脏学
CiteScore
22.40
自引率
2.90%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the American Society of Nephrology (JASN) stands as the preeminent kidney journal globally, offering an exceptional synthesis of cutting-edge basic research, clinical epidemiology, meta-analysis, and relevant editorial content. Representing a comprehensive resource, JASN encompasses clinical research, editorials distilling key findings, perspectives, and timely reviews. Editorials are skillfully crafted to elucidate the essential insights of the parent article, while JASN actively encourages the submission of Letters to the Editor discussing recently published articles. The reviews featured in JASN are consistently erudite and comprehensive, providing thorough coverage of respective fields. Since its inception in July 1990, JASN has been a monthly publication. JASN publishes original research reports and editorial content across a spectrum of basic and clinical science relevant to the broad discipline of nephrology. Topics covered include renal cell biology, developmental biology of the kidney, genetics of kidney disease, cell and transport physiology, hemodynamics and vascular regulation, mechanisms of blood pressure regulation, renal immunology, kidney pathology, pathophysiology of kidney diseases, nephrolithiasis, clinical nephrology (including dialysis and transplantation), and hypertension. Furthermore, articles addressing healthcare policy and care delivery issues relevant to nephrology are warmly welcomed.
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