ELECTROCHEMOTHERAPY WITH CISPLATIN FOR THE TREATMENT OF A NON-OPERABLE ORAL SQUAMOUS CELL CARCINOMA IN A LOWLAND TAPIR (TAPIRUS TERRESTRIS).

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES Journal of Zoo and Wildlife Medicine Pub Date : 2025-03-01 DOI:10.1638/2023-0132

Rúbia M C Cunha, Gleidice E Lavalle, Roberto B Araújo, Herlandes P Tinoco, Carlyle M Coelho, Fabíola de Oliveira Paes Leme, Anelise C Nepomuceno, Luiz A Lago, Daniel O Santos, Renato L Santos, Marcelo P N de Carvalho

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Abstract

Squamous cell carcinoma (SCC) is a malignant epidermal tumor. Biologic behavior and metastasis rate vary according to species and tumor location. The goal of this study was to report the occurrence and behavior of an oral SCC in a Tapirus terrestris treated with electrochemotherapy. The tapir was anesthetized for two electrochemotherapy sessions, six months apart, with intralesional cisplatin (0.25 mL/cm³) and VetCP 125^TM electroporator. Side effects were minimal. Because of tumor relapse, onset of joint disorders, and poor prognosis, the animal was euthanized and submitted to necropsy, followed by histopathological and immunohistochemical analyses. Electrochemotherapy significantly improved the tapiŕs life quality. Tumor bleeding resolved, and food uptake was improved. Necropsy demonstrated tumor invasion in adjacent soft tissues and bones and submandibular lymph nodes with multiple areas of metastasis. Overall survival time of 35 months was achieved, with good life quality. Histopathologic characteristics were more aggressive in the relapsed tumor.

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顺铂电化疗治疗不能手术的低地貘口腔鳞状细胞癌。

鳞状细胞癌是一种恶性表皮肿瘤。生物学行为和转移率因肿瘤种类和位置而异。本研究的目的是报道经化疗治疗的地貘口腔鳞状细胞癌的发生和行为。用0.25 mL/cm3的顺铂和VetCP 125TM电穿孔器麻醉貘进行两次化疗，间隔6个月。副作用很小。由于肿瘤复发，关节疾病发作，预后不良，动物被安乐死并提交尸检，随后进行组织病理学和免疫组织化学分析。电疗显著提高tapiŕs患者的生活质量。肿瘤出血消退，食物摄取改善。尸检显示肿瘤侵袭邻近的软组织和骨骼和下颌淋巴结，并有多处转移。总生存时间35个月，生活质量良好。复发肿瘤的组织病理学特征更具侵袭性。

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来源期刊

Journal of Zoo and Wildlife Medicine 农林科学-兽医学

CiteScore

1.70

自引率

14.30%

发文量

审稿时长

9-24 weeks

期刊介绍： The Journal of Zoo and Wildlife Medicine (JZWM) is considered one of the major sources of information on the biology and veterinary aspects in the field. It stems from the founding premise of AAZV to share zoo animal medicine experiences. The Journal evolved from the long history of members producing case reports and the increased publication of free-ranging wildlife papers. The Journal accepts manuscripts of original research findings, case reports in the field of veterinary medicine dealing with captive and free-ranging wild animals, brief communications regarding clinical or research observations that may warrant publication. It also publishes and encourages submission of relevant editorials, reviews, special reports, clinical challenges, abstracts of selected articles and book reviews. The Journal is published quarterly, is peer reviewed, is indexed by the major abstracting services, and is international in scope and distribution. Areas of interest include clinical medicine, surgery, anatomy, radiology, physiology, reproduction, nutrition, parasitology, microbiology, immunology, pathology (including infectious diseases and clinical pathology), toxicology, pharmacology, and epidemiology.