Jiajia Hu , Jiyuan Cao , Huixin Cheng , Xiaojin Liu , Guoying Zhang , Jianya Ling
{"title":"Anti-breast cancer effect of Phellinus pini and its chemical composition characterization","authors":"Jiajia Hu , Jiyuan Cao , Huixin Cheng , Xiaojin Liu , Guoying Zhang , Jianya Ling","doi":"10.1016/j.fitote.2025.106480","DOIUrl":null,"url":null,"abstract":"<div><div><em>Phellinus pini</em> (<em>P. pini</em>) has been widely utilized as a traditional medicinal macrofungus in China and various East Asian countries. Modern pharmacological studies have shown that <em>P. pini</em> has important application value in anti-tumor therapy. However, its main anti-breast cancer active substances and mechanism are still unclear. In this study, we demonstrated that the methanol extract of <em>Phellinus pini</em> (PPE) could significantly inhibit the viability of 4 T1 cells, induce apoptosis, decrease mitochondrial membrane potential and S phase arrest of 4 T1 cells. PPE can restore the imbalance of intestinal flora caused by breast cancer and regulate the content of endogenous metabolites such as amino acids. Q Exactive UPLC-MS/MS analysis showed that polyphenols are the main chemical components that exert the efficacy. These results provide experimental support for the potential future treatment of breast cancer with <em>P. pini</em>.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"182 ","pages":"Article 106480"},"PeriodicalIF":2.5000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X25001054","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Phellinus pini (P. pini) has been widely utilized as a traditional medicinal macrofungus in China and various East Asian countries. Modern pharmacological studies have shown that P. pini has important application value in anti-tumor therapy. However, its main anti-breast cancer active substances and mechanism are still unclear. In this study, we demonstrated that the methanol extract of Phellinus pini (PPE) could significantly inhibit the viability of 4 T1 cells, induce apoptosis, decrease mitochondrial membrane potential and S phase arrest of 4 T1 cells. PPE can restore the imbalance of intestinal flora caused by breast cancer and regulate the content of endogenous metabolites such as amino acids. Q Exactive UPLC-MS/MS analysis showed that polyphenols are the main chemical components that exert the efficacy. These results provide experimental support for the potential future treatment of breast cancer with P. pini.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
