Phytosomes: A promising nanocarrier system for enhanced bioavailability and therapeutic efficacy of herbal products

Q3 Pharmacology, Toxicology and Pharmaceutics Phytomedicine Plus Pub Date : 2025-03-07 DOI:10.1016/j.phyplu.2025.100779

Marjan Talebi , Kimia Shahbazi , Mohammad Sedigh Dakkali , Marziyeh Akbari , Rouzbeh Almasi Ghale , Seyedali Hashemi , Mahdyeh Sashourpour , Faraz Mojab , Saeed Aminzadeh

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Abstract

Background

Herbal products have revealed a variety of therapeutic potential in numerous health conditions. However, limitations regarding their solubility, absorption, bioavailability, and stability have hindered clinical translations. Among various strategies to combat these challenges, using phytosomes as a nanocarrier system has presented a promising approach to enhance the bioavailability and effectiveness of phytoconstituents.

Purpose

This study comprehensively reviews the development, preparation, and advantages of phytosomes as a novel nanodelivery system, focusing on overcoming the pharmacokinetic limitations of phytoconstituents.

Methods

A scientific literature search was conducted using databases including PubMed, Web of Science, Scopus, and Google Scholar. Keywords such as “phytosome,” “herbasome,” “herbal drug delivery,” and “phospholipid complex” were employed to identify appropriate scientific articles.

Results

Phytosomal delivery systems have demonstrated significant improvements in bioavailability, therapeutic outcomes, stability, and targeted distribution of herbal products. Compared to other delivery systems like liposomes, phytosomes exhibit superior pharmacokinetic profiles and distribution efficiency. They show promise in enhancing bioavailability and enabling diverse routes of administration, including oral, topical, and intranasal. They also have numerous therapeutic applications in inflammatory diseases, neurological disorders, cancers, metabolic syndrome, and liver diseases.

Conclusion

Phytosomal delivery systems effectively address the pharmacokinetic challenges of herbal products, offering improved bioavailability, stability, and therapeutic outcomes.

Abstract Image