Synthesis of Agcl Cube/Porous Carbon Nanotubes Composition for Nonenzymatic Electrochemically Sensing H2O2 Released from Cancer Cells

IF 2.3 3区化学 Q2 CHEMISTRY, ANALYTICAL Electroanalysis Pub Date : 2025-03-13 DOI:10.1002/elan.12039

Na Zhang, Yilin Wu, Yan Wang, Yongxiang Su, Xvsheng Xie, Hongyan Wang, Keying Zhang, Rongli Jiang

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Abstract

The abnormal expression of hydrogen peroxide (H₂O₂) in living cells is closely related to the occurrence and development of tumor diseases. It is a kind potential marker for tumor diagnosis and treatment of tumor diseases. Therefore, it is very meaningful to develop high selective and sensitive method for real-time detecting H₂O₂ released from cancer cells. Herein, an AgCl cube/porous carbon nanotube composite nanomaterials was successfully fabricated and employed to construct a non-enzymatic electrochemical H₂O₂ sensor. Test results showed that the proposed sensor displayed the high sensitivity with the detection limit of 5.3 × 10⁻⁹ mol/L (S/N = 3). Importantly, it can accurately analyze H₂O₂ in milk samples and achieve real-time determination of H₂O₂ secreted from living cancer cells. In addition, the established sensor exhibited good stability and anti-interference ability. This strategy offers a potential way to diagnose tumor diseases.

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Agcl立方/多孔碳纳米管非酶电化学传感癌细胞释放H2O2的合成

活细胞中过氧化氢（H2O2）的异常表达与肿瘤疾病的发生发展密切相关。它是一种潜在的肿瘤诊断和治疗标志物。因此，开发高选择性、高灵敏度的实时检测肿瘤细胞释放的H2O2的方法具有十分重要的意义。本文成功制备了AgCl立方体/多孔碳纳米管复合纳米材料，并将其用于构建非酶电化学H2O2传感器。实验结果表明，该传感器具有较高的灵敏度，检测限为5.3 × 10−9 mol/L （S/N = 3）。重要的是，它可以准确地分析牛奶样品中的H2O2，实现实时测定活癌细胞分泌的H2O2。此外，所建立的传感器具有良好的稳定性和抗干扰能力。这一策略为肿瘤疾病的诊断提供了一种潜在的方法。

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来源期刊

Electroanalysis 化学-电化学

CiteScore

6.00

自引率

3.30%

发文量

222

审稿时长

2.4 months

期刊介绍： Electroanalysis is an international, peer-reviewed journal covering all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with new electrochemical sensors and biosensors, nanobioelectronics devices, analytical voltammetry, potentiometry, new electrochemical detection schemes based on novel nanomaterials, fuel cells and biofuel cells, and important practical applications. Serving as a vital communication link between the research labs and the field, Electroanalysis helps you to quickly adapt the latest innovations into practical clinical, environmental, food analysis, industrial and energy-related applications. Electroanalysis provides the most comprehensive coverage of the field and is the number one source for information on electroanalytical chemistry, electrochemical sensors and biosensors and fuel/biofuel cells.