Judit Hostalet-Romero, Laura Carceller-Ferrer, Gonzalo Blay, Amparo Sanz-Marco, José R Pedro, Carlos Vila
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引用次数: 0
Abstract
A valuable vinylogous addition reaction between 4-alkylidene-5-aminopyrazoles and alkyl trifluoropyruvates leading to highly functionalized tertiary alcohols bearing a trifluoromethyl group and a pyrazole ring is presented. The corresponding trifluoromethyl alcohols are obtained in moderate to good yields (up to 80%) and high diastereoselectivity (up to 7:1).
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