Ho-Ching Yang, Tyler Nguyen, Fletcher A White, Kelly M Naugle, Yu-Chien Wu
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引用次数: 0
Abstract
Background: This study used diffusion tensor imaging (DTI) to detect brain microstructural changes in participants with mild traumatic brain injury (mTBI) who experienced post-traumatic headaches, a common issue that affects quality of life and rehabilitation. Despite its prevalence, the mechanisms behind post-traumatic headache are not well understood. Methods: Participants were recruited from Level 1 trauma centers, and MRI scans, including T1-weighted anatomical imaging and DTI, were acquired 1 month post-injury. Advanced imaging techniques corrected artifacts and extracted diffusion tensor measures reflecting white-matter integrity. Pain sensitivity assays were collected at 1 and 6 months post-injury, including quantitative sensory testing and psychological assessments. Results: Significant aberrations in axial diffusivity in the forceps major were observed in mTBI participants (n = 12) compared to healthy controls (n = 10) 1 month post-injury (p = 0.02). Within the mTBI group, DTI metrics at 1 month were significantly associated with pain-related and psychological outcomes at 6 months. Statistical models revealed group differences in the right sagittal stratum (p < 0.01), left insula (p < 0.04), and left superior longitudinal fasciculus (p < 0.05). Conclusions: This study shows that DTI metrics at 1 month post-injury are sensitive to mTBI and predictive of chronic pain and psychological outcomes at 6 months.
DiagnosticsBiochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍:
Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.