Inter-Software Reproducibility of Quantitative Values of Myocardial Blood Flow and Coronary Flow Reserve Acquired by [13N]NH3 MPI PET/CT and the Effect of Motion Correction Tools.
Oscar Isaac Mendoza-Ibañez, Riemer H J A Slart, Erick Alexanderson-Rosas, Tonantzin Samara Martinez-Lucio, Friso M van der Zant, Remco J J Knol, Sergiy V Lazarenko
{"title":"Inter-Software Reproducibility of Quantitative Values of Myocardial Blood Flow and Coronary Flow Reserve Acquired by [<sup>13</sup>N]NH<sub>3</sub> MPI PET/CT and the Effect of Motion Correction Tools.","authors":"Oscar Isaac Mendoza-Ibañez, Riemer H J A Slart, Erick Alexanderson-Rosas, Tonantzin Samara Martinez-Lucio, Friso M van der Zant, Remco J J Knol, Sergiy V Lazarenko","doi":"10.3390/diagnostics15050613","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> The choice of software package (SP) for image processing affects the reproducibility of myocardial blood flow (MBF) values in [<sup>13</sup>N]NH<sub>3</sub> PET/CT scans. However, the impact of motion correction (MC) tools-integrated software motion correction (ISMC) or data-driven motion correction (DDMC)-on the inter-software reproducibility of MBF has not been studied. This research aims to evaluate reproducibility among three commonly used SPs and the role of MC. <b>Methods:</b> Thirty-six PET/CT studies from patients without myocardial ischemia or infarction were processed using QPET, Corridor-4DM (4DM), and syngo.MBF (syngo). MBF and coronary flow reserve (CFR) values were obtained without motion correction (NMC) and with ISMC and DDMC. Intraclass correlation coefficients (ICC) and Bland-Altman (BA) plots were used to analyze agreement. <b>Results:</b> Good or excellent reproducibility (ICC ≥ 0.77) was found for rest-MBF values, regardless of the SPs or use of MC. In contrast, stress-MBF and CFR values presented mostly a moderate agreement when NMC was used. The RCA territory consistently had the lowest agreement in stress-MBF and CFR in the comparisons involving QPET. The use of MC, particularly DDMC, enhanced the reproducibility of most of the stress-MBF and CFR values by improving ICCs and reducing bias and limits of agreement (LoA) in BA analysis. <b>Conclusions:</b> MBF quantification agreement between SPs is strong for rest-MBF values but suboptimal for stress-MBF and CFR values. MC tools, especially DDMC, are recommended for improving reproducibility in stress-MBF assessments, although differences in SP reproducibility up to 0.77 mL/g/min in global stress-MBF and up to 0.88 in global CFR remain despite the use of MC.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 5","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898590/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/diagnostics15050613","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The choice of software package (SP) for image processing affects the reproducibility of myocardial blood flow (MBF) values in [13N]NH3 PET/CT scans. However, the impact of motion correction (MC) tools-integrated software motion correction (ISMC) or data-driven motion correction (DDMC)-on the inter-software reproducibility of MBF has not been studied. This research aims to evaluate reproducibility among three commonly used SPs and the role of MC. Methods: Thirty-six PET/CT studies from patients without myocardial ischemia or infarction were processed using QPET, Corridor-4DM (4DM), and syngo.MBF (syngo). MBF and coronary flow reserve (CFR) values were obtained without motion correction (NMC) and with ISMC and DDMC. Intraclass correlation coefficients (ICC) and Bland-Altman (BA) plots were used to analyze agreement. Results: Good or excellent reproducibility (ICC ≥ 0.77) was found for rest-MBF values, regardless of the SPs or use of MC. In contrast, stress-MBF and CFR values presented mostly a moderate agreement when NMC was used. The RCA territory consistently had the lowest agreement in stress-MBF and CFR in the comparisons involving QPET. The use of MC, particularly DDMC, enhanced the reproducibility of most of the stress-MBF and CFR values by improving ICCs and reducing bias and limits of agreement (LoA) in BA analysis. Conclusions: MBF quantification agreement between SPs is strong for rest-MBF values but suboptimal for stress-MBF and CFR values. MC tools, especially DDMC, are recommended for improving reproducibility in stress-MBF assessments, although differences in SP reproducibility up to 0.77 mL/g/min in global stress-MBF and up to 0.88 in global CFR remain despite the use of MC.
DiagnosticsBiochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍:
Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.