[Perforation of Small Intestinal Gastrointestinal Stromal Tumor Required Emergency Surgery-A Case Report].

Q4 Medicine Japanese Journal of Cancer and Chemotherapy Pub Date : 2025-02-01
Masanori Ikota, Taku Akahoshi, Ippei Murata, Rama Adikrisna, Tomoyuki Ohta, Kenjiro Kitasato, Sho Mineta, Yoshihiko Tsuruta
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Abstract

The case was a 77-year-old man. He presented with abdominal pain and melena to our hospital. Abdominal CT showed thickening of the small intestinal wall and findings of intraperitoneal free air. Suspecting peritonitis due to small intestinal tumor perforation, we performed an emergency surgery. A ruptured tumor measuring 50 mm in diameter was found in the jejunum about 15 cm from the Treitz' ligament and the partial resection of the small intestine was performed. Histopathology revealed fistulous necrosis within the tumor, and immunostaining was positive for KIT and CD34, leading to the diagnosis of jejunal GIST. He was evaluated as high risk for recurrence and was indicated for adjuvant chemotherapy. He is currently taking imatinib and is being followed up for 6 months without recurrence. Although diagnosing GIST of small intestine can be difficult, GIST of small intestine with perforation is at high risk of recurrence and rezuires adjuvant chemotherapy. Emergency surgical diagnosis should not be hesitated.

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【小肠胃肠道间质瘤穿孔急诊手术1例】。
该病例为一名77岁男子。他以腹痛和黑黑症来我们医院就诊。腹部CT显示小肠壁增厚,腹腔内有游离空气。我们怀疑腹膜炎是由小肠肿瘤穿孔引起的,我们进行了紧急手术。在距Treitz韧带约15 cm的空肠内发现直径50 mm的肿瘤破裂,并行小肠部分切除。组织病理学显示肿瘤内瘘样坏死,免疫染色KIT和CD34阳性,诊断为空肠GIST。他被评估为复发的高风险,并指示进行辅助化疗。目前正在服用伊马替尼,随访6个月无复发。虽然小肠间质瘤的诊断很困难,但小肠间质瘤伴穿孔的复发风险很高,需要辅助化疗。急诊手术诊断应毫不犹豫。
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