Carriers of a Single Cystic Fibrosis Transmembrane Conductance Regulator Pathogenic Variant and COVID-19 in Pregnancy: A Retrospective Cohort Study

Abstract

COVID-19 outcomes are worse in non-pregnant patients who are cystic fibrosis carriers; however, no studies have examined COVID-19 outcomes in pregnant patients who are cystic fibrosis carriers. We evaluated the cystic fibrosis carrier status of pregnant patients with COVID-19 in 3 geographical regions in the United States and compared the outcomes between non-carriers and carriers. Of 2430 pregnant patients with COVID-19, 229 had a cystic fibrosis screen. Pregnant cystic fibrosis carriers were associated with 47.90 times greater odds of hospitalization with COVID-19 than non-carriers. A larger cohort will be needed to draw strong conclusions.