Short wave infrared band Spatial-Temporal-Spectral resolved sensing system and its application in bio-samples measurement

Abstract

Recently, due to its high penetration depth and molecular monitoring capabilities, the optical sensing and imaging of biological tissues in the short-wave infrared band have attracted much attention. However, because of the limitations of the spectral response bands of traditional indium gallium arsenide-based (InGaAs) detectors and CMOS chips, most of the research on biological tissue in the SWIR band mainly focuses on the 1150 nm–1700 nm band. High-throughput optical sensing in the 1700 nm–2200 nm wavelength band is relatively rarely reported. In this work, a novel biological tissue spectral detection prototype was developed, which mainly contains an electrically switchable fiber bundle probe and short-wave infrared spectrometers, to achieve optical detection of biological tissues in the spatial, temporal, and spectral domains within the 1150 nm–2200 nm band. Based on an improved Monte Carlo simulation as a forward problem model, spatial and spectral domain information were used to reconstruct the absorption and scattering coefficients of biological tissues within the 1150 nm–2200 nm band. By utilizing time-domain data, pulse wave information can be extracted from skin tissue. It offers a comprehensive solution with significant potential for detailed optical parameter analysis and sensitive bio-molecule quantification in the short-wave infrared band.