{"title":"Quantitative corneal nerve beading analysis: A novel biomarker for Parkinson's disease progression","authors":"Sasi Yaisawang , Inturat Attapinan , Ngamjit Kasetsuwan , Usanee Reinprayoon , Krit Pongpirul , Roongroj Bhidayasiri , Jirada Sringean","doi":"10.1016/j.parkreldis.2025.107764","DOIUrl":null,"url":null,"abstract":"<div><div>This study compared corneal nerve beading between Parkinson's disease (PD) patients and healthy controls. Results showed increases in both density and size of nerve beadings in PD, which correlated with disease severity and duration. Corneal nerve beading demonstrated high sensitivity as a potential biomarker for diagnosing and monitoring PD progression.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"134 ","pages":"Article 107764"},"PeriodicalIF":3.4000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parkinsonism & related disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S135380202500505X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study compared corneal nerve beading between Parkinson's disease (PD) patients and healthy controls. Results showed increases in both density and size of nerve beadings in PD, which correlated with disease severity and duration. Corneal nerve beading demonstrated high sensitivity as a potential biomarker for diagnosing and monitoring PD progression.
期刊介绍：
Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.
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