A Novel Approach to the Prediction of Alzheimer’s Disease Progression by Leveraging Neural Processes and a Transformer Encoder Model

IF 3.4 3区 计算机科学 Q2 COMPUTER SCIENCE, INFORMATION SYSTEMS IEEE Access Pub Date : 2025-03-05 DOI:10.1109/ACCESS.2025.3548173
Emad Al-Anbari;Hossein Karshenas;Bijan Shoushtarian
{"title":"A Novel Approach to the Prediction of Alzheimer’s Disease Progression by Leveraging Neural Processes and a Transformer Encoder Model","authors":"Emad Al-Anbari;Hossein Karshenas;Bijan Shoushtarian","doi":"10.1109/ACCESS.2025.3548173","DOIUrl":null,"url":null,"abstract":"Alzheimer’s disease (AD) presents a significant global health challenge, necessitating accurate and early prediction methods for effective intervention and treatment planning. In this work, a novel approach to meta-learning for the prediction of AD is proposed, which leverages the combined power of neural processes (NPs) and transformer architectures. We introduce a framework that integrates NPs with a transformer encoder to model the complex temporal dependencies inherent in longitudinal health data, where our model learns to capture subtle patterns and variations indicative of disease progression. The novelty of our approach lies in the fusion of NPs, renowned for their ability to model stochastic processes, with transformer architectures, known for their ability to capture long-range dependencies. This combination enables our model to effectively adapt to individual patient trajectories and generalize across diverse populations, enhancing its predictive performance and robustness. We trained our proposed model with the Alzheimer’s Disease Prediction Of Longitudinal Evolution dataset (TADPOLE), which contains three classes: Cognitively Normal (CN), Mild Cognitive Impairment (MCI), and AD. The experimental results demonstrate that the proposed model enhances the prediction of these models in terms of mAUC, Recall, and Precision by <inline-formula> <tex-math>$0.937\\pm 0.014$ </tex-math></inline-formula>, <inline-formula> <tex-math>$0.920\\pm 0.010$ </tex-math></inline-formula>, and <inline-formula> <tex-math>$0.923\\pm 0.009$ </tex-math></inline-formula>, respectively. These findings prove the efficacy of the proposed framework in accurately predicting the progression of AD, highlighting its potential for early detection and personalized treatment strategies.","PeriodicalId":13079,"journal":{"name":"IEEE Access","volume":"13 ","pages":"44607-44619"},"PeriodicalIF":3.4000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10910173","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Access","FirstCategoryId":"94","ListUrlMain":"https://ieeexplore.ieee.org/document/10910173/","RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"COMPUTER SCIENCE, INFORMATION SYSTEMS","Score":null,"Total":0}
引用次数: 0

Abstract

Alzheimer’s disease (AD) presents a significant global health challenge, necessitating accurate and early prediction methods for effective intervention and treatment planning. In this work, a novel approach to meta-learning for the prediction of AD is proposed, which leverages the combined power of neural processes (NPs) and transformer architectures. We introduce a framework that integrates NPs with a transformer encoder to model the complex temporal dependencies inherent in longitudinal health data, where our model learns to capture subtle patterns and variations indicative of disease progression. The novelty of our approach lies in the fusion of NPs, renowned for their ability to model stochastic processes, with transformer architectures, known for their ability to capture long-range dependencies. This combination enables our model to effectively adapt to individual patient trajectories and generalize across diverse populations, enhancing its predictive performance and robustness. We trained our proposed model with the Alzheimer’s Disease Prediction Of Longitudinal Evolution dataset (TADPOLE), which contains three classes: Cognitively Normal (CN), Mild Cognitive Impairment (MCI), and AD. The experimental results demonstrate that the proposed model enhances the prediction of these models in terms of mAUC, Recall, and Precision by $0.937\pm 0.014$ , $0.920\pm 0.010$ , and $0.923\pm 0.009$ , respectively. These findings prove the efficacy of the proposed framework in accurately predicting the progression of AD, highlighting its potential for early detection and personalized treatment strategies.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
IEEE Access
IEEE Access COMPUTER SCIENCE, INFORMATION SYSTEMSENGIN-ENGINEERING, ELECTRICAL & ELECTRONIC
CiteScore
9.80
自引率
7.70%
发文量
6673
审稿时长
6 weeks
期刊介绍: IEEE Access® is a multidisciplinary, open access (OA), applications-oriented, all-electronic archival journal that continuously presents the results of original research or development across all of IEEE''s fields of interest. IEEE Access will publish articles that are of high interest to readers, original, technically correct, and clearly presented. Supported by author publication charges (APC), its hallmarks are a rapid peer review and publication process with open access to all readers. Unlike IEEE''s traditional Transactions or Journals, reviews are "binary", in that reviewers will either Accept or Reject an article in the form it is submitted in order to achieve rapid turnaround. Especially encouraged are submissions on: Multidisciplinary topics, or applications-oriented articles and negative results that do not fit within the scope of IEEE''s traditional journals. Practical articles discussing new experiments or measurement techniques, interesting solutions to engineering. Development of new or improved fabrication or manufacturing techniques. Reviews or survey articles of new or evolving fields oriented to assist others in understanding the new area.
期刊最新文献
High-Performance NTRU Accelerator Using a Direct Memory Access Controller Corrections to “A Visual Prompt-Based Mobile Learning System for Improved Algebraic Understanding in Students With Learning Disabilities” Utility Meets Privacy: A Critical Evaluation of Tabular Data Synthesizers Minimizing Delay at Closely Spaced Signalized Intersections Through Green Time Ratio Optimization: A Hybrid Approach With K-Means Clustering and Genetic Algorithms Analysis and Design of mmWave Passive CMOS Circulators With Unequal Port Impedances
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1