Advances in Transition Metal-Catalyzed C(sp2)–H Bond Functionalization Using Allyl Alcohols

IF 3.3 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemistry - An Asian Journal Pub Date : 2025-03-14 DOI:10.1002/asia.202401930
Dhananjay S. Nipate, Vani Dhyani, Tarun Jangir, Prof. Tharmalingam Punniyamurthy, Prof. Anil Kumar
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Abstract

The transition metal-catalyzed directed site-selective C─H bond functionalization utilizing allyl alcohols as coupling partner has been an intriguing area of research and has made considerable advances during the past decade. Multifunctional coupling characteristics of the allyl alcohol in the regioselective C(sp2)–H functionalization using transition metal-catalysis produces alkyl, alkenyl, allyl, and annulated products. These reactions provide an effective synthetic tool to afford diverse functionalized scaffolds that are of interest in synthetic and medicinal sciences. This review covers the developments of directed site-selective C(sp2)–H functionalization with unactivated allyl alcohols as the coupling partner using the transition metal-catalysis till December, 2024.

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烯丙醇催化过渡金属催化C(sp2)-氢键功能化的研究进展。
利用烯丙醇作为偶联伙伴的过渡金属催化的定向位点选择性C-H键功能化是一个有趣的研究领域,在过去的十年中取得了相当大的进展。在过渡金属催化下,丙烯醇在C(sp2)-H功能化过程中的多功能偶联特性产生烷基、烯基、烯基和环状产物。这些反应提供了一种有效的合成工具,以提供合成和医学科学中感兴趣的各种功能化支架。本文综述了截至2024年10月,以未活化的烯丙醇为偶联体,利用过渡金属催化进行定向位点选择性C(sp2)-H功能化的研究进展。
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来源期刊
Chemistry - An Asian Journal
Chemistry - An Asian Journal 化学-化学综合
CiteScore
7.00
自引率
2.40%
发文量
535
审稿时长
1.3 months
期刊介绍: Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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