Jiyun Hu, Shucai Xie, Ya Liao, Tao Chen, Zhaoxin Qian, Lina Zhang
{"title":"The gender paradox in sepsis: Exploring male vulnerability and female resilience","authors":"Jiyun Hu, Shucai Xie, Ya Liao, Tao Chen, Zhaoxin Qian, Lina Zhang","doi":"10.1016/j.amjsurg.2025.116293","DOIUrl":null,"url":null,"abstract":"<div><div>The role of gender in sepsis outcomes remains controversial. Numerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have yielded conflicting evidence. While the literature varies, most studies indicate that male gender is associated with worse sepsis outcomes and survival. Understanding the gender's role in these processes provides valuable insights into potential therapeutic targets for sepsis.</div></div>","PeriodicalId":7771,"journal":{"name":"American journal of surgery","volume":"247 ","pages":"Article 116293"},"PeriodicalIF":2.7000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of surgery","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002961025001151","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/7 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
The role of gender in sepsis outcomes remains controversial. Numerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have yielded conflicting evidence. While the literature varies, most studies indicate that male gender is associated with worse sepsis outcomes and survival. Understanding the gender's role in these processes provides valuable insights into potential therapeutic targets for sepsis.
期刊介绍：
The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.
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