Systemic Immune-Inflammatory Index as a Prognostic Biomarker in Patients with Heart Failure: A Comprehensive Analysis.

IF 2 4区医学 Q2 HEMATOLOGY Clinical and Applied Thrombosis/Hemostasis Pub Date : 2025-01-01 Epub Date: 2025-03-13 DOI:10.1177/10760296251328361

Aihaidan Abudouwayiti, Yanxiao Li, Tumaresi Tuerxun, Muyashaer Abudurexiti, Dongqin Duan, Ying-Ying Zheng, Ailiman Mahemuti

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Abstract

ObjectiveThis study aimed to assess the prognostic significance of the Systemic Immune-Inflammatory Index (SII) in chronic heart failure (CHF) patients and evaluate its potential as a predictive biomarker.MethodsA retrospective analysis was conducted on 2748 CHF patients from the First Affiliated Hospital of Xinjiang Medical University from 2012 to 2022. The primary outcome was all-cause mortality (ACM), with readmission rates as secondary endpoints. An optimal SII cutoff value of 916.68 was determined for predicting ACM.ResultsElevated SII levels were significantly correlated with an increased risk of ACM in CHF patients across all left ventricular ejection fraction (LVEF) categories. The high SII group had a 43.8% increased risk of ACM compared to the low SII group.ConclusionSII is a significant prognostic biomarker in CHF, independent of traditional risk factors, highlighting its importance in risk stratification and clinical decision-making, and necessitating further investigation in prospective studies.

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作为心力衰竭患者预后生物标志物的全身免疫炎症指数：综合分析

目的本研究旨在评估慢性心力衰竭（CHF）患者全身免疫炎症指数（SII）的预后意义，并评估其作为预测性生物标记物的潜力。方法对新疆医科大学第一附属医院2012年至2022年的2748例CHF患者进行回顾性分析。主要结果为全因死亡率（ACM），再入院率为次要终点。结果在所有左心室射血分数（LVEF）类别中，SII水平升高与CHF患者ACM风险增加显著相关。结论SII是独立于传统风险因素的一种重要的CHF预后生物标志物，突显了其在风险分层和临床决策中的重要性，有必要在前瞻性研究中进一步探讨。

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来源期刊

Clinical and Applied Thrombosis/Hemostasis 医学-外周血管病

CiteScore

4.40

自引率

3.40%

发文量

150

审稿时长

2 months

期刊介绍： CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.