Aspergillus fumigatus from Pathogenic Fungus to Unexplored Natural Treasure: Changing the Concept.

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of microbiology and biotechnology Pub Date : 2025-03-11 DOI:10.4014/jmb.2411.11082
Sabrin R M Ibrahim, Hagar Mohamed Mohamed, Anfal S Aljahdali, Samar S A Murshid, Shaimaa G A Mohamed, Hossam M Abdallah, Gamal A Mohamed
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引用次数: 0

Abstract

The Aspergillus genus is one of the oldest known fungal genera. Its species can survive in extremely difficult environmental conditions and can affect plants, animals, and human health due to their pathogenic characteristics. Also, they represent an enormous chemical and biological repertoire. A. fumigatus is a fungal pathogen that has been thoroughly investigated due to its medical significance. Additionally, A. fumigatus has revealed a capacity to biosynthesize different classes of secondary metabolites such as alkaloids, terpenes, sterols, quinones, peptides, and benzophenones. Alkaloids are the most common type of secondary metabolites that A. fumigatus produces, and they have a variety of biological functions. This current study aimed to highlight the positive aspects of this fungus. The published research on the structures, biological functions, and biosynthesis of A. fumigatus's isolated metabolites were emphasized in this work. The current review comprised more than 400 compounds, with more than 145 references that were published between 1965 and August 2024. This review underscores the role of this fungus as a reservoir of bioactive compounds with antimicrobial, anticancer, anti-inflammatory, and agricultural applications.

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来源期刊
Journal of microbiology and biotechnology
Journal of microbiology and biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MICROBIOLOGY
CiteScore
5.50
自引率
3.60%
发文量
151
审稿时长
2 months
期刊介绍: The Journal of Microbiology and Biotechnology (JMB) is a monthly international journal devoted to the advancement and dissemination of scientific knowledge pertaining to microbiology, biotechnology, and related academic disciplines. It covers various scientific and technological aspects of Molecular and Cellular Microbiology, Environmental Microbiology and Biotechnology, Food Biotechnology, and Biotechnology and Bioengineering (subcategories are listed below). Launched in March 1991, the JMB is published by the Korean Society for Microbiology and Biotechnology (KMB) and distributed worldwide.
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