Cordycepin's therapeutic potential: in vivo transport, transbilayer diffusion and anti-aging effects

IF 3.5 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of the Science of Food and Agriculture Pub Date : 2025-03-14 DOI:10.1002/jsfa.14220

Xiaoliang Zhang, Sijia Wu, Qihan Huang, Shubo Jing, Pang Yong, Ling Zhang, Hong Zhuang

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Abstract

BACKGROUND

Cordycepin (3′-deoxyadenosine) is a bioactive compound known for its numerous beneficial properties, including antioxidant, anti-aging and antitumor effects. Despite its promising therapeutic potential, the in vivo transport mechanisms of cordycepin remain inadequately understood. Previous studies have highlighted its biological activity, but there is limited information regarding its transport and distribution, as well as how it interacts with biological systems to exert these effects. The present study explored the transport mechanisms of cordycepin, specifically its interaction with bovine serum albumin (BSA) transporters and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes, and assessed its anti-aging effects through cellular experiments.

RESULTS

The study demonstrates that cordycepin effectively interacts with DPPC liposomes, improving its therapeutic efficacy. Spectral analysis shows strong binding between cordycepin and transporters, aiding its distribution in the bloodstream and targeted accumulation in tissues. Additionally, cellular tests reveal that cordycepin inhibits butyl hydroperoxide-induced cellular senescence in a dose-dependent manner.

CONCLUSION

The interaction of cordycepin with BSA transporters and DPPC liposomes enhances its distribution and therapeutic potential. The compound also shows promise as an anti-aging agent by reducing cellular senescence. These findings provide insight into cordycepin's in vivo behavior and suggest strategies to enhance its pharmacological effectiveness. © 2025 Society of Chemical Industry.

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虫草素的治疗潜力：体内转运、跨双分子层扩散和抗衰老作用。

背景：虫草素（3'-脱氧腺苷）是一种生物活性化合物，具有许多有益的特性，包括抗氧化，抗衰老和抗肿瘤作用。尽管其具有良好的治疗潜力，但冬虫夏草素的体内转运机制仍不充分了解。以前的研究已经强调了它的生物活性，但是关于它的运输和分布，以及它如何与生物系统相互作用来发挥这些作用的信息有限。本研究探讨了虫草素的转运机制，特别是其与牛血清白蛋白（BSA）转运体和1,2-二棕榈酰- n-甘油-3-磷脂胆碱（DPPC）脂质体的相互作用，并通过细胞实验评估了其抗衰老作用。结果：虫草素可与DPPC脂质体有效相互作用，提高其治疗效果。光谱分析显示，冬虫夏草素与转运蛋白之间有很强的结合，有助于其在血液中的分布和在组织中的靶向积累。此外，细胞试验显示虫草素以剂量依赖的方式抑制丁基氢过氧化物诱导的细胞衰老。结论：冬虫夏草素与BSA转运体和DPPC脂质体的相互作用增强了其分布和治疗潜力。该化合物还显示出通过减少细胞衰老作为抗衰老剂的希望。这些发现为虫草素的体内行为提供了见解，并提出了提高其药理效力的策略。©2025化学工业协会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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文献相关原料

公司名称

产品信息

索莱宝

BSA

麦克林

Cordycepin

麦克林

Cordycepin

来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.