Cordycepin's therapeutic potential: in vivo transport, transbilayer diffusion and anti-aging effects.

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of the Science of Food and Agriculture Pub Date : 2025-03-14 DOI:10.1002/jsfa.14220

Xiaoliang Zhang, Sijia Wu, Qihan Huang, Shubo Jing, Pang Yong, Ling Zhang, Hong Zhuang

{"title":"Cordycepin's therapeutic potential: in vivo transport, transbilayer diffusion and anti-aging effects.","authors":"Xiaoliang Zhang, Sijia Wu, Qihan Huang, Shubo Jing, Pang Yong, Ling Zhang, Hong Zhuang","doi":"10.1002/jsfa.14220","DOIUrl":null,"url":null,"abstract":"Background: Cordycepin (3'-deoxyadenosine) is a bioactive compound known for its numerous beneficial properties, including antioxidant, anti-aging and antitumor effects. Despite its promising therapeutic potential, the in vivo transport mechanisms of cordycepin remain inadequately understood. Previous studies have highlighted its biological activity, but there is limited information regarding its transport and distribution, as well as how it interacts with biological systems to exert these effects. The present study explored the transport mechanisms of cordycepin, specifically its interaction with bovine serum albumin (BSA) transporters and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes, and assessed its anti-aging effects through cellular experiments.Results: The study demonstrates that cordycepin effectively interacts with DPPC liposomes, improving its therapeutic efficacy. Spectral analysis shows strong binding between cordycepin and transporters, aiding its distribution in the bloodstream and targeted accumulation in tissues. Additionally, cellular tests reveal that cordycepin inhibits butyl hydroperoxide-induced cellular senescence in a dose-dependent manner.Conclusion: The interaction of cordycepin with BSA transporters and DPPC liposomes enhances its distribution and therapeutic potential. The compound also shows promise as an anti-aging agent by reducing cellular senescence. These findings provide insight into cordycepin's in vivo behavior and suggest strategies to enhance its pharmacological effectiveness. © 2025 Society of Chemical Industry.","PeriodicalId":17725,"journal":{"name":"Journal of the Science of Food and Agriculture","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Science of Food and Agriculture","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1002/jsfa.14220","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Cordycepin (3'-deoxyadenosine) is a bioactive compound known for its numerous beneficial properties, including antioxidant, anti-aging and antitumor effects. Despite its promising therapeutic potential, the in vivo transport mechanisms of cordycepin remain inadequately understood. Previous studies have highlighted its biological activity, but there is limited information regarding its transport and distribution, as well as how it interacts with biological systems to exert these effects. The present study explored the transport mechanisms of cordycepin, specifically its interaction with bovine serum albumin (BSA) transporters and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes, and assessed its anti-aging effects through cellular experiments.

Results: The study demonstrates that cordycepin effectively interacts with DPPC liposomes, improving its therapeutic efficacy. Spectral analysis shows strong binding between cordycepin and transporters, aiding its distribution in the bloodstream and targeted accumulation in tissues. Additionally, cellular tests reveal that cordycepin inhibits butyl hydroperoxide-induced cellular senescence in a dose-dependent manner.

Conclusion: The interaction of cordycepin with BSA transporters and DPPC liposomes enhances its distribution and therapeutic potential. The compound also shows promise as an anti-aging agent by reducing cellular senescence. These findings provide insight into cordycepin's in vivo behavior and suggest strategies to enhance its pharmacological effectiveness. © 2025 Society of Chemical Industry.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.