Understanding Mortality Patterns in Elderly Cancer Patients with Atrial Fibrillation: A Comprehensive Data Analysis

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL American Journal of the Medical Sciences Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI:10.1016/j.amjms.2025.03.004

Muhammad Abdullah Naveed MBBS , Sivaram Neppala MD , Shehroze Tabassum MD , Ahila Ali MBBS , Himaja Dutt Chigurupati MD , Muhammad Omer Rehan MBBS , Rabia Iqbal MBBS , Bazil Azeem MBBS , Hamza Naveed MBBS , Mushood Ahmed MBBS , Jamal Rana MD , Bilal Munir MD

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Abstract

Background

Atrial Fibrillation (AF) among patients with cancer is a significant health concern for older adults in the United States. This study analyzes trends and demographic disparities in mortality rates related to AF in patients with cancer aged 65+.

Methods

The CDC WONDER database was used to analyze Age-adjusted mortality rates (AAMRs) for to AF in patients with cancer (ICD-10 I48, C00- C97) from 1999 to 2023, stratified by sex, race, geography, and metropolitan status. Average Annual Percentage Changes (AAPCs) and Annual Percentage Changes (APCs) per 100,000 with 95 % confidence intervals (CI) calculated using Joinpoint regression.

Results

From 1999 to 2023, AF in patients with cancer caused 421,247 deaths among U.S. adults 65+. The overall AAMR rose from 24.1 in 1999 to 61.1 in 2023, with a 3.92 AAPC (95 % CI: 3.81 to 4.05). AAMR increased significantly from 1999 to 2018 (APC: 3.12), surged from 2018 to 2021 (APC: 10.93), then rose slightly until 2023 (APC: 1.40), all p <0.01. From 1999 to 2023, Men had higher AAMRs than women (53.8 vs. 27.2) while NH Whites had the highest AAMRs (42.2), followed by NH Blacks (23.1). Vermont has the highest AAMR (60.0), Nevada the lowest (17.3), and the Western region had the highest AAMR (40.8), while rural areas had slightly higher AAMRs than urban areas (39.1 vs 34.8).

Conclusion

The AAMR for AF in patients with cancer in the U.S. has doubled over the past two decades, particularly during the COVID-19 pandemic. These findings highlight the urgent need for targeted interventions and enhanced access to care.

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了解老年癌症患者心房颤动的死亡率模式：一项综合数据分析。

背景：癌症患者心房颤动（AF）是美国老年人的一个重要健康问题。本研究分析了65岁以上癌症患者AF相关死亡率的趋势和人口统计学差异。方法：采用CDC WONDER数据库分析1999 - 2023年癌症（icd - 1048,c00 - C97）患者AF的年龄调整死亡率（AAMRs），按性别、种族、地理和城市状况分层。平均年变化百分比（AAPCs）和每10万人的年变化百分比（APCs）， 95%置信区间（CI）使用Joinpoint回归计算。结果：从1999年到2023年，美国65岁以上成年人中，癌症患者AF导致421,247人死亡。总体AAMR从1999年的24.1上升到2023年的61.1，AAPC为3.92 （95% CI: 3.81至4.05）。从1999年到2018年，AAMR显著增加（APC: 3.12），从2018年到2021年激增（APC: 10.93），然后略有上升，直到2023年（APC: 1.40）。结论：美国癌症患者AF的AAMR在过去二十年中翻了一番，特别是在COVID-19大流行期间。这些发现突出表明，迫切需要采取有针对性的干预措施，并增加获得护理的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of the Medical Sciences 医学-医学：内科

CiteScore

4.40

自引率

0.00%

发文量

303

审稿时长

1.5 months

期刊介绍： The American Journal of The Medical Sciences (AJMS), founded in 1820, is the 2nd oldest medical journal in the United States. The AJMS is the official journal of the Southern Society for Clinical Investigation (SSCI). The SSCI is dedicated to the advancement of medical research and the exchange of knowledge, information and ideas. Its members are committed to mentoring future generations of medical investigators and promoting careers in academic medicine. The AJMS publishes, on a monthly basis, peer-reviewed articles in the field of internal medicine and its subspecialties, which include: Original clinical and basic science investigations Review articles Online Images in the Medical Sciences Special Features Include: Patient-Centered Focused Reviews History of Medicine The Science of Medical Education.