Chasing the “White Plague” in the Barbaricum of the Carpathian Basin – A case with tuberculous meningitis discovered in a Sarmatian-period (2nd–3rd-century-CE) storage pit from the archaeological site of Kiskundorozsma–Daruhalom-dűlő II (Hungary)

IF 2.9 3区 医学 Q3 IMMUNOLOGY Tuberculosis Pub Date : 2025-05-01 Epub Date: 2025-03-12 DOI:10.1016/j.tube.2025.102632
Ágota Madai , Marcos De Andrés Montero , Luca Kis , Csaba Szalontai , Anna Szigeti , István Major , Attila Kiss P. , Olga Spekker
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Abstract

The aim of our paper is to demonstrate a case (KD429) with tuberculous meningitis (TBM) from the 2nd–3rd‒century‒CE Carpathian Basin. The skeleton of KD429 was subject to a detailed macromorphological evaluation, focusing on the detection of pathological lesions likely related to tuberculosis (TB). It was the presence of endocranial alterations, especially the TB-specific granular impressions, based on which the diagnosis of TBM was established in KD429. Besides KD429, only eight cases with TB have been published from the Sarmatian-period (1st–5th centuries CE) Carpathian Basin. Reports of archaeological cases with TB, like KD429, can provide invaluable information about the spatio-temporal distribution of the disease in the past. Nonetheless, to get a more accurate picture about the burden that TB may have put on the Sarmatians, the systematic macromorphological (re-)evaluation of their osteoarchaeological series would be advantageous. Interestingly, the skeleton of KD429 was unearthed from not a grave-pit but a storage pit from the archaeological site of Kiskundorozsma–Daruhalom-dűlő II (Hungary). At the current state of research, the motive behind the exclusion of KD429 from the “normal” burial custom cannot be determined; therefore, it remains an open question whether their disease (TBM) played a role in it or not.
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在喀尔巴阡盆地的野蛮地区追逐“白色瘟疫”——在匈牙利Kiskundorozsma-Daruhalom-dűlő II考古遗址的一个萨尔马提亚时期(公元2 - 3世纪)的储存坑中发现的一例结核性脑膜炎病例
我们的论文的目的是证明一个病例(KD429)结核性脑膜炎(TBM)来自公元2 - 3世纪的喀尔巴阡盆地。对KD429的骨骼进行了详细的宏观形态学评估,重点是检测可能与结核病(TB)相关的病理病变。正是颅内改变的存在,特别是结核病特异性颗粒印象,在KD429中建立了TBM的诊断。除KD429外,萨尔马时期(公元1 - 5世纪)喀尔巴阡盆地仅报告了8例结核病例。关于结核病考古病例的报告,如KD429,可以提供有关该疾病过去时空分布的宝贵信息。尽管如此,为了更准确地了解结核病可能给萨尔马特人带来的负担,对他们的骨考古系列进行系统的宏观形态学(重新)评估将是有利的。有趣的是,KD429的骨架不是从坟墓中出土的,而是从Kiskundorozsma-Daruhalom-dűlő II(匈牙利)考古遗址的一个储存坑中出土的。在目前的研究状态下,无法确定将KD429排除在“正常”丧葬习俗之外的动机;因此,他们的疾病(TBM)是否在其中起作用仍然是一个悬而未决的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tuberculosis
Tuberculosis 医学-呼吸系统
CiteScore
4.60
自引率
3.10%
发文量
87
审稿时长
49 days
期刊介绍: Tuberculosis is a speciality journal focusing on basic experimental research on tuberculosis, notably on bacteriological, immunological and pathogenesis aspects of the disease. The journal publishes original research and reviews on the host response and immunology of tuberculosis and the molecular biology, genetics and physiology of the organism, however discourages submissions with a meta-analytical focus (for example, articles based on searches of published articles in public electronic databases, especially where there is lack of evidence of the personal involvement of authors in the generation of such material). We do not publish Clinical Case-Studies. Areas on which submissions are welcomed include: -Clinical TrialsDiagnostics- Antimicrobial resistance- Immunology- Leprosy- Microbiology, including microbial physiology- Molecular epidemiology- Non-tuberculous Mycobacteria- Pathogenesis- Pathology- Vaccine development. This Journal does not accept case-reports. The resurgence of interest in tuberculosis has accelerated the pace of relevant research and Tuberculosis has grown with it, as the only journal dedicated to experimental biomedical research in tuberculosis.
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