{"title":"Common marmoset: An emerging non-human primate model for translational applications in brain disorders","authors":"Yefei Chen , William Menegas , Qiangge Zhang , Guoping Feng","doi":"10.1016/j.conb.2025.102998","DOIUrl":null,"url":null,"abstract":"<div><div>One of the fundamental challenges for modern neuroscience has been to translate discoveries from model organisms into effective therapeutics for human brain disorders. This challenge partly arises from the structural and functional differences between rodent and human brains [1]. To bridge this gap, non-human primates (NHPs) can be used as an intermediate step because of their genetic, physiological, and behavioral similarities to humans. Among NHPs, the common marmoset has become a valuable animal model in neuroscience research due to its fast generation time and unique biological and behavioral characteristics [2]. In this review, we first summarize the progress toward developing models for brain disorders. We then discuss emerging technologies and resources that will help advance our understanding of the neurobiological mechanisms underlying different brain disorders using marmoset genetic models. Finally, we describe using marmoset models to test novel therapeutic approaches such as gene therapy and neural circuit manipulation.</div></div>","PeriodicalId":10999,"journal":{"name":"Current Opinion in Neurobiology","volume":"92 ","pages":"Article 102998"},"PeriodicalIF":4.8000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Neurobiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0959438825000297","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
One of the fundamental challenges for modern neuroscience has been to translate discoveries from model organisms into effective therapeutics for human brain disorders. This challenge partly arises from the structural and functional differences between rodent and human brains [1]. To bridge this gap, non-human primates (NHPs) can be used as an intermediate step because of their genetic, physiological, and behavioral similarities to humans. Among NHPs, the common marmoset has become a valuable animal model in neuroscience research due to its fast generation time and unique biological and behavioral characteristics [2]. In this review, we first summarize the progress toward developing models for brain disorders. We then discuss emerging technologies and resources that will help advance our understanding of the neurobiological mechanisms underlying different brain disorders using marmoset genetic models. Finally, we describe using marmoset models to test novel therapeutic approaches such as gene therapy and neural circuit manipulation.
期刊介绍:
Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance.
The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives.
Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories:
-Neurobiology of Disease-
Neurobiology of Behavior-
Cellular Neuroscience-
Systems Neuroscience-
Developmental Neuroscience-
Neurobiology of Learning and Plasticity-
Molecular Neuroscience-
Computational Neuroscience