Li-Jun Li, Xin-Yue Li, Jin Zhang, Hong Li, Qiang-Wei Fan, Yang Li
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引用次数: 0
Abstract
The presence of trifluoromethyl in the drug molecule can effectively improve its lipophilicity, absorbability, and metabolic stability. Therefore, the introduction of trifluoromethyl in organic molecules has attracted widespread attention. In recent years, the trifluoromethylation of olefins has been developed rapidly. In this paper, various synthesis methods and reaction mechanisms of trifluoromethylated olefins in recent years are reviewed from the perspectives of transition metal (Cu, Fe, Pd, Ni) catalysis and photocatalysis and free radical reactions.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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