Biomedical implication of microfluidics in disease diagnosis and therapeutics: from fabrication to prognosis.

IF 8.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Biofabrication Pub Date : 2025-03-14 DOI:10.1088/1758-5090/adc0c2
Shivani Yadav, Manish Dwivedi, Sukriti Singh, Pooja Jangir
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Abstract

Microfluidics has given us an approach to regulate the fluids' behaviour and influence at the microscale level, including the microchannels as an integral element. Microchannels encompass the high surface area-to-volume ratio, causing the rapid diffusion and mixing of substances within the tiny canals and facilitating predictable and stable fluid dynamics. This precise regulatory mechanism of fluid behaviour by microchannels is significant for several biological and chemical processes. In the present scenario, microfluidics plays a significant role in pharmaceutical industries for efficient drug synthesis, DNA analysis, protein crystallization and cell culture. They have also been exploited in fabricating site-directed drug delivery systems such as microchannels. This review has illustrated the different strategies for fabricating microfluidic devices (e.g. microchannels) and their potential implications in biomedical sciences. It also includes a discussion about the challenges associated with standardisation, cost-effective production, biocompatibility and safety concerning microchannel fabrication and its biological application, as well as possible approaches to overcome these issues. These microfluidic devices have the potential for diagnosis, drug delivery, disease monitoring and other applications in human health and diseases and require more attention from researchers to fabricate them precisely and efficiently.

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微流体技术为我们提供了一种在微观层面上调节流体行为和影响的方法,其中微通道是一个不可或缺的元素。微通道具有较高的表面积与体积比,可使物质在微小的通道内快速扩散和混合,并促进可预测的稳定流体动力学。微通道对流体行为的这种精确调控机制对一些生物和化学过程具有重要意义。目前,微流体技术在制药业的高效药物合成、DNA 分析、蛋白质结晶和细胞培养中发挥着重要作用。在制造微通道等定点给药系统方面,微流控技术也得到了利用。本综述阐述了制造微流体设备(如微通道)的不同策略及其在生物医学科学中的潜在影响。文章还讨论了微通道制造及其生物应用在标准化、生产成本效益、生物兼容性和安全性方面面临的挑战,以及克服这些问题的可行方法。这些微流控装置在人类健康和疾病的诊断、药物输送、疾病监测和其他应用方面具有潜力,需要研究人员更加关注如何精确、高效地制造它们。
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来源期刊
Biofabrication
Biofabrication ENGINEERING, BIOMEDICAL-MATERIALS SCIENCE, BIOMATERIALS
CiteScore
17.40
自引率
3.30%
发文量
118
审稿时长
2 months
期刊介绍: Biofabrication is dedicated to advancing cutting-edge research on the utilization of cells, proteins, biological materials, and biomaterials as fundamental components for the construction of biological systems and/or therapeutic products. Additionally, it proudly serves as the official journal of the International Society for Biofabrication (ISBF).
期刊最新文献
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