Current Biomarkers of IgA Nephropathy.

IF 2.8 3区 医学 Q2 UROLOGY & NEPHROLOGY Seminars in nephrology Pub Date : 2025-03-13 DOI:10.1016/j.semnephrol.2025.151572
Fahmeedah Kamal, Jackson Kim, Richard Lafayette
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Abstract

IgA nephropathy (IgAN) is the most prevalent primary glomerular disease and has been recognized to carry a poor prognosis. It is therefore critical to identify the patients that will progress to ESKD and start treatments early. The current gold standard for diagnosis remains kidney biopsy. Histopathologic findings along with proteinuria, glomerular filtration rate, and hypertension remain the best-validated biomarkers for prognosis but do not provide enough granularity to guide treatment decisions. The current understanding of the pathophysiology of IgAN with the four-hit hypothesis has helped identify potential additional biomarkers that could become available in the foreseeable future. In this review we detail the existing data for the most promising biomarkers including galactose-deficient IgA1 and its corresponding autoantibody, markers of complement activation, as well as more nascent assays such as MicroRNAs, genomic, and microbiome biomarkers.

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IgA 肾病(IgAN)是最常见的原发性肾小球疾病,预后较差。因此,识别将发展为 ESKD 的患者并尽早开始治疗至关重要。目前诊断的金标准仍然是肾活检。组织病理学检查结果以及蛋白尿、肾小球滤过率和高血压仍是预后的最佳生物标志物,但其精细程度不足以指导治疗决策。目前对 IgAN 病理生理学的理解和四击假说有助于确定在可预见的将来可能出现的其他生物标志物。在这篇综述中,我们详细介绍了最有前景的生物标志物的现有数据,包括半乳糖缺乏的 IgA1 及其相应的自身抗体、补体激活标志物,以及 MicroRNA、基因组和微生物组生物标志物等新兴检测方法。
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来源期刊
Seminars in nephrology
Seminars in nephrology 医学-泌尿学与肾脏学
CiteScore
5.60
自引率
0.00%
发文量
27
审稿时长
6-12 weeks
期刊介绍: Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.
期刊最新文献
Current Biomarkers of IgA Nephropathy. Emerging Biochemical and Immunologic Mechanisms in the Pathogenesis of IgA Nephropathy. Post-transplant IgA Nephropathy. The Genetics of IgA Nephropathy: Implications for Future Therapies. IgA Nephropathy: Epidemiology and Disease Risk Across the World.
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