Prevention and control of HPV-related cancers in people living with HIV.

IF 12.8 1区 医学 Q1 IMMUNOLOGY Lancet Hiv Pub Date : 2025-03-11 DOI:10.1016/S2352-3018(25)00011-6
Anneli Uusküla, Anna Tisler, Jack DeHovitz, Gad Murenzi, Philip E Castle, Gary Clifford
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Abstract

The advent of effective antiretroviral therapy (ART) has increased the lifespan of many people living with HIV. As a result, cancers driven by high-risk human papillomavirus (HPV) infection have emerged as an increasingly important cause of mortality in this population. The complex interplay between HIV and HPV necessitates a deep understanding of the HPV-related cancer burden in people living with HIV and the integration of effective prevention strategies into their care. Although cervical cancer is a global concern, anal cancer is more important among people living with HIV in settings where HIV is more concentrated among men who have sex with men. High HPV prevalence, coupled with resource constraints, particularly in sub-Saharan Africa, where the majority of people living with HIV reside, creates substantial barriers to successful prevention and management of HPV-related malignancies. Implementing preventive measures, such as HPV vaccination and comprehensive screening programmes, is crucial and will require addressing existing health inequities and developing tailored interventions for people living with HIV. The development of enhanced secondary prevention tools and innovative treatment modalities is essential to mitigate the burden of HPV-associated cancers and improve the overall health outcomes for this vulnerable population.

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有效的抗逆转录病毒疗法(ART)的出现延长了许多艾滋病病毒感染者的寿命。因此,由高危人乳头瘤病毒(HPV)感染引发的癌症已成为这一人群日益重要的死亡原因。HIV 与 HPV 之间复杂的相互作用要求我们深入了解 HIV 感染者中与 HPV 相关的癌症负担,并将有效的预防策略融入到他们的护理中。虽然宫颈癌是一个全球关注的问题,但在艾滋病病毒感染者更集中于男男性行为者的环境中,肛门癌在艾滋病病毒感染者中的发病率更高。HPV 感染率高,再加上资源限制,尤其是在撒哈拉以南非洲地区(大多数艾滋病病毒感染者居住在该地区),为成功预防和管理 HPV 相关恶性肿瘤造成了巨大障碍。实施 HPV 疫苗接种和全面筛查计划等预防措施至关重要,需要解决现有的健康不平等问题,并为艾滋病毒感染者制定量身定制的干预措施。开发强化的二级预防工具和创新的治疗模式,对于减轻人乳头瘤病毒相关癌症的负担和改善这一弱势群体的总体健康状况至关重要。
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来源期刊
Lancet Hiv
Lancet Hiv IMMUNOLOGYINFECTIOUS DISEASES&-INFECTIOUS DISEASES
CiteScore
19.90
自引率
4.30%
发文量
368
期刊介绍: The Lancet HIV is an internationally trusted source of clinical, public health, and global health knowledge with an Impact Factor of 16.1. It is dedicated to publishing original research, evidence-based reviews, and insightful features that advocate for change in or illuminates HIV clinical practice. The journal aims to provide a holistic view of the pandemic, covering clinical, epidemiological, and operational disciplines. It publishes content on innovative treatments and the biological research behind them, novel methods of service delivery, and new approaches to confronting HIV/AIDS worldwide. The Lancet HIV publishes various types of content including articles, reviews, comments, correspondences, and viewpoints. It also publishes series that aim to shape and drive positive change in clinical practice and health policy in areas of need in HIV. The journal is indexed by several abstracting and indexing services, including Crossref, Embase, Essential Science Indicators, MEDLINE, PubMed, SCIE and Scopus.
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