Effect of the Extraction Method and Conditions on the Content of Polyphenols in Buckwheat Fagopyrum esculentum Husk Extracts and Their Acetylcholinesterase-Inhibiting Activity
S. S. Khizrieva, S. N. Borisenko, E. V. Maksimenko, A. V. Ippolitova, K. O. Shchedrina, N. I. Borisenko, V. I. Minkin
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引用次数: 0
Abstract
The effect of the extraction method and conditions on the polyphenolic composition of buckwheat Fagopyrum esculentum husk extracts and their activity in inhibiting acetylcholinesterase (AChE) was studied. The extracts were obtained both by the conventional method of water–ethanol extraction and in a subcritical water medium at 120–220°C. A direct correlation was found between the anticholinesterase activity and the content of polyphenols in the extracts. The highest activity in inhibiting AChE was shown by the extract obtained in the subcritical water medium at 220°C, which contained the maximum amounts of polyphenols and flavonoids. This indicates the decisive role of these compounds in inhibiting AChE. The obtained data allow one to consider buckwheat husk extracts as inexpensive and renewable sources of polyphenolic compounds and flavonoids with P-vitamin and neuroprotective activity.
期刊介绍：
Russian Journal of Physical Chemistry B: Focus on Physics is a journal that publishes studies in the following areas: elementary physical and chemical processes; structure of chemical compounds, reactivity, effect of external field and environment on chemical transformations; molecular dynamics and molecular organization; dynamics and kinetics of photoand radiation-induced processes; mechanism of chemical reactions in gas and condensed phases and at interfaces; chain and thermal processes of ignition, combustion and detonation in gases, two-phase and condensed systems; shock waves; new physical methods of examining chemical reactions; and biological processes in chemical physics.
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