Front Cover: Beyond the Toll-Like Receptor 4. Structure-Dependent Lipopolysaccharide Recognition Systems: How far are we? (ChemMedChem 6/2025)

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL ChemMedChem Pub Date : 2025-03-16 DOI:10.1002/cmdc.202580601

Stefania De Chiara, Luca De Simone Carone, Roberta Cirella, Dr. Emanuela Andretta, Prof. Alba Silipo, Prof. Antonio Molinaro, Dr. Marcello Mercogliano, Prof. Flaviana Di Lorenzo

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Abstract

Gram-negative bacteria release lipopolysaccharides (LPS) into our bodies, acting as potent modulators of inflammation. These molecules can enhance or attenuate inflammation. Beyond the largely studied MD2/TLR4, a complex set of other receptors interact with LPS producing diverse effects. Understanding how the structural features of LPS affect the activity and crosstalk among various receptors is crucial for developing new drugs to treat immune-related pathologies. This review aims to persuade researchers with interest in this field to perform their research activities by always using a structure to function approach. More details can be found in article cmdc.202400780 by Marcello Mercogliano, Flaviana Di Lorenzo, and co-workers.

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封面：超越 Toll-Like 受体 4。结构依赖性脂多糖识别系统：我们还有多远？(ChemMedChem 6/2025)

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.