Lipid Nanoparticle-Mediated CRISPR-Cas13a Delivery for the Control of Bacterial Infection (Adv. Healthcare Mater. 7/2025)

IF 9.6 2区 医学 Q1 ENGINEERING, BIOMEDICAL Advanced Healthcare Materials Pub Date : 2025-03-17 DOI:10.1002/adhm.202570040
Bookun Kim, Hwi Won Seo, Kyuri Lee, Dongeun Yong, Yoon Kyung Park, Yujin Lee, Solip Lee, Do-Wan Kim, Dajeong Kim, Choong-Min Ryu
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Abstract

Bacteria-Targeting Lipid Nanoparticle

In article 2403281, Dajeong Kim, Choong-Min Ryu, and co-workers develop a lipid nanoparticle (LNP) that can penetrate bacteria and deliver nucleic acids for the control of bacterial infection. Delivery of LNPs is achieved with the aid of “LNP-helpers”, yellow granules treated on the bacterial surface. The LNP is a novel antimicrobial platform that controls bacteria by delivering the CRISPR-Cas system as a weapon.

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脂质纳米粒子介导的 CRISPR-Cas13a 释放技术用于控制细菌感染(Adv.)
在文章2403281中,Dajeong Kim, Choong-Min Ryu等人开发了一种可以穿透细菌并传递核酸的脂质纳米颗粒(LNP),用于控制细菌感染。LNPs的递送是在“lnp辅助剂”的帮助下实现的,这种黄色颗粒在细菌表面处理过。LNP是一种新型抗菌平台,通过传递CRISPR-Cas系统作为武器来控制细菌。
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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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