Sensitization profile of Thai children with fish allergy.

IF 2.1 4区医学 Q3 ALLERGY Allergologia et immunopathologia Pub Date : 2025-03-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i2.1209

Supaluk Tangvalelerd, Surapon Piboonpocanun, Unchalee Raungsirarak, Manaporn Sirichuwong, Pakit Vichyanond, Punchama Pacharn

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Abstract

Introduction: Fish allergies are common food allergies, and in Thailand, the prevalence of fish allergies in children ranges from 0.29% to 1.1%. Common fish allergens include parvalbumin, enolase, and aldolase.

Method: This cross-sectional study included children with immunoglobulin E (IgE)-mediated fish allergies. The diagnosis was based on clinical history with a positive skin prick test (SPT) and/or specific IgE (sIgE). Serum IgE binding profiles to allergens in fish extracts were analyzed.

Result: Eleven children, with a median age of 3 years, were recruited; the median age of onset was 1.25 years. Cutaneous symptoms were the most frequent clinical manifestation (63.6%). Tilapia and catfish were the most common triggers. All participants showed positive SPT and/or sIgE results for fish species. The immunoblot analysis revealed IgE binding to 40-50 kDa protein in all participants, while only seven participants (63.6%) showed IgE binding to the 11 kDa protein.

Conclusion: Tilapia and catfish are the most common triggers of fish allergies in Thai children. The 40-50 kDa proteins were identified as a major fish allergen in tested cohort.

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泰国鱼过敏儿童的致敏特征

鱼类过敏是常见的食物过敏，在泰国，儿童对鱼类过敏的患病率为0.29%至1.1%。常见的鱼类过敏原包括细小蛋白、烯醇化酶和醛缩酶。方法：这项横断面研究包括免疫球蛋白E （IgE）介导的鱼类过敏儿童。诊断基于临床病史，皮肤点刺试验（SPT）和/或特异性IgE （sIgE）阳性。分析了鱼提取物中血清IgE对过敏原的结合谱。结果：招募了11名儿童，中位年龄为3岁；中位发病年龄为1.25岁。皮肤症状是最常见的临床表现（63.6%）。罗非鱼和鲶鱼是最常见的诱因。所有参与者对鱼类的SPT和/或sIgE结果均为阳性。免疫印迹分析显示，所有参与者的IgE与40-50 kDa蛋白结合，而只有7名参与者（63.6%）显示IgE与11 kDa蛋白结合。结论：罗非鱼和鲶鱼是泰国儿童最常见的鱼类过敏诱因。40-50 kDa蛋白被鉴定为主要的鱼类过敏原。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.