{"title":"No causal link between smoking and dementia with Lewy bodies","authors":"Yu-Liang Gao , Qiu-Han Xu","doi":"10.1016/j.parkreldis.2025.107775","DOIUrl":null,"url":null,"abstract":"<div><div>This letter addresses the findings of Goodheart and Gomperts (2024), which observed an association between smoking and reduced odds of dementia with Lewy bodies (DLB). In contrast, our Mendelian randomization analysis found no causal link, suggesting that further research using genetically informed methods is needed to clarify these results.</div></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"135 ","pages":"Article 107775"},"PeriodicalIF":3.4000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parkinsonism & related disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1353802025005164","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/11 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
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Abstract
This letter addresses the findings of Goodheart and Gomperts (2024), which observed an association between smoking and reduced odds of dementia with Lewy bodies (DLB). In contrast, our Mendelian randomization analysis found no causal link, suggesting that further research using genetically informed methods is needed to clarify these results.
期刊介绍：
Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.
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