{"title":"Cover Feature: Endoplasmic Reticulum-Targeting Delayed Fluorescent Probe for Dual-mode Nitroreductase Sensing (Chem. Asian J. 6/2025)","authors":"V. T. K. Shradha, Subhadeep Das, Abhijit Patra","doi":"10.1002/asia.202580603","DOIUrl":null,"url":null,"abstract":"<p>The study highlights an innovative approach to developing a highly selective delayed fluorescent probe for the dual-mode detection of a cancer hallmark within the endoplasmic reticulum (ER, depicted as a greenish-blue structure). The ER-specific probe, designed for selective detection of nitroreductase (NTR, shown in orange), is initially in a non-fluorescent state (grey). Upon interacting with NTR, the probe activates, emitting green fluorescence and long-lived emission, enabling intracellular detection through luminescence and time-resolved imaging modes symbolized by clock icons. More details can be found in article number e202401226 by Abhijit Patra and co-workers.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"20 6","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/asia.202580603","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry - An Asian Journal","FirstCategoryId":"1","ListUrlMain":"https://aces.onlinelibrary.wiley.com/doi/10.1002/asia.202580603","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
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Abstract
The study highlights an innovative approach to developing a highly selective delayed fluorescent probe for the dual-mode detection of a cancer hallmark within the endoplasmic reticulum (ER, depicted as a greenish-blue structure). The ER-specific probe, designed for selective detection of nitroreductase (NTR, shown in orange), is initially in a non-fluorescent state (grey). Upon interacting with NTR, the probe activates, emitting green fluorescence and long-lived emission, enabling intracellular detection through luminescence and time-resolved imaging modes symbolized by clock icons. More details can be found in article number e202401226 by Abhijit Patra and co-workers.
期刊介绍：
Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics.
Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews.
A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal.
Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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