{"title":"Update for oxidopyridinium cycloadditions and their synthetic applications. Advances after the Katritzky’s pioneering studies","authors":"Yoshihiko Yamamoto","doi":"10.1039/d5qo00115c","DOIUrl":null,"url":null,"abstract":"Since the pioneering studies of the Katritzky group, the cycloaddition of 3-oxidopyridinium betaines has been continuously studied because (1) the multifaceted reactivity of 3-oxidopyridiniums has attracted attention from the viewpoint of physical chemistry, and (2) the production of nitrogen heterocycles with three-dimensional frameworks is crucial for natural product chemistry and pharmaceutical sciences. In this review, the development of oxidopyridinium cycloadditions is discussed. First, the results of the seminal investigations on oxidopyridinium cycloadditions are briefly presented. Subsequently, the follow-up research conducted since the pioneering studies of Katritzky and others is discussed.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"14 1","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Chemistry Frontiers","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5qo00115c","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Since the pioneering studies of the Katritzky group, the cycloaddition of 3-oxidopyridinium betaines has been continuously studied because (1) the multifaceted reactivity of 3-oxidopyridiniums has attracted attention from the viewpoint of physical chemistry, and (2) the production of nitrogen heterocycles with three-dimensional frameworks is crucial for natural product chemistry and pharmaceutical sciences. In this review, the development of oxidopyridinium cycloadditions is discussed. First, the results of the seminal investigations on oxidopyridinium cycloadditions are briefly presented. Subsequently, the follow-up research conducted since the pioneering studies of Katritzky and others is discussed.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.