Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer: Call for a Multidisciplinary Approach

IF 25.2 1区 医学 Q1 UROLOGY & NEPHROLOGY European urology Pub Date : 2025-07-01 Epub Date: 2025-03-17 DOI:10.1016/j.eururo.2025.02.029
Rajal B. Shah , Gladell P. Paner , Liang Cheng , Angelo M. De Marzo , Cristina Magi-Galluzzi , Murali Varma , Ming Zhou , Ali Amin , Mahul B. Amin , Manju Aron , Isabela W. Cunha , Jonathan I. Epstein , Samson W. Fine , Aiman Haider , Kenneth A. Iczkowski , James G. Kench , Lakshmi Priya Kunju , Sambit K. Mohanty , Rodolfo Montironi , George J. Netto , Glen Kristiansen
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泌尿生殖病理学会和国际泌尿病理学会定义惰性前列腺癌白皮书:呼吁多学科方法
切片snippetsHow检测无痛性前列腺癌无痛性前列腺癌只能在根治性前列腺切除术(RP)中完全切除的前列腺组织中检测到。在完全检查的RP标本中检测到的GG - 1 PC的结果非常好。在RP标本中含有纯GG - 1型PC的病例中,没有发生转移到淋巴结和远处部位和PC特异性死亡(PCSM)。前列腺外展不常见(高达6%),精囊侵犯罕见(0.03%)。在膀胱前列腺切除术标本中偶然发现的大多数前列腺癌是GG 1惰性前列腺癌能可靠地在活检中检测到吗?针活检(NBx)的GG - 1pc诊断并不总是与RP的GG - 1pc诊断相同。不可能在NBx可靠地识别不活跃的PC。NBx的GG 1 pc子集在RP升级到更高的等级。尽管结合了磁共振成像(MRI)靶向和系统活检,由于采样错误或潜在的进展,22-27%的活检GG - 1 PC病例仍发生RP的实质性升级[3,4]。如何提高对NBx惰性PC的正确分类能力?通过当代多学科方法,可以改善NBx惰性PC的最佳定义。当代的“组织病理学定义”包括(未定义)大多数无痛性PC,包括g1型,无模糊的gp3 / gp4型,无筛状PC(筛状gp4 /导管内癌),无间质结缔组织增生(“间质性”PC)。这种组织病理学定义必须与其他多学科因素相结合,以最佳识别惰性PC。
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来源期刊
European urology
European urology 医学-泌尿学与肾脏学
CiteScore
43.00
自引率
2.60%
发文量
1753
审稿时长
23 days
期刊介绍: European Urology is a peer-reviewed journal that publishes original articles and reviews on a broad spectrum of urological issues. Covering topics such as oncology, impotence, infertility, pediatrics, lithiasis and endourology, the journal also highlights recent advances in techniques, instrumentation, surgery, and pediatric urology. This comprehensive approach provides readers with an in-depth guide to international developments in urology.
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