Target-induced reconstruction of Ru(bpy)32+-loaded gold nanocage for one-step highly sensitive detection of Hg2+

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL Talanta Pub Date : 2025-09-01 Epub Date: 2025-03-17 DOI:10.1016/j.talanta.2025.127955

Jin Wang , Xinyu Lu , Huafeng Wang , Yuan Zhong , Zhihui Dai , Tianxiang Wei

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Abstract

In this work, Ru(bpy)₃²⁺-loaded gold nanocage (AuNCs) (Ru–AuNCs) was prepared and found to display a distinct property of electrochemiluminescence (ECL) enhancement under mercury ions (Hg²⁺) interaction. Based on this, we designed a screen-printed bipolar electrode-ECL (SPBPE-ECL) sensing platform by coupling with the thymine-Hg²⁺-thymine (T-Hg²⁺-T) binding pattern for one-step highly sensitive detection of Hg²⁺. This ECL sensor showed a wide linear detection range (0.75 – 850 μg L⁻¹) and low detection limit (0.1290 μg L⁻¹) toward Hg²⁺, with a one-step detection procedure and disposable feature, displaying potential applicability in the point-of-care-testing (POCT) of Hg²⁺ in the environment. In addition, the Hg²⁺-mediated ECL signal enhancement mechanism of Ru–AuNCs was also investigated. It was confirmed that Hg²⁺ interaction etched the cage structure of Ru–AuNCs, which sped up the release of more Ru(bpy)₃²⁺ around the sensing electrode. Furthermore, Au–Hg alloy structure was formed on the surface of Ru–AuNCs, which also improved the ECL signal. This target-induced in-situ sensing material surface reconstruction strategy would provide a better design concept for the construction of ECL POCT sensor.

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靶诱导重构负载Ru(bpy)32+的金纳米笼一步高灵敏度检测Hg2+

在这项工作中，制备了负载Ru(bpy)32+的金纳米笼（Ru - AuNCs），并发现在汞离子（Hg2+）相互作用下显示出明显的电化学发光（ECL）增强特性。在此基础上，我们设计了一个丝网印刷双极电极- ecl （SPBPE-ECL）传感平台，结合胸腺嘧啶-Hg2+-胸腺嘧啶（T-Hg2+-T）结合模式，用于一步高灵敏度检测Hg2+。该ECL传感器对Hg2+具有较宽的线性检测范围（0.75 ~ 850 μg L−1）和较低的检出限（0.1290 μg L−1），具有一步检测流程和一次性使用的特点，在环境中Hg2+的即时检测（POCT）中具有潜在的适用性。此外，我们还研究了Hg2+介导的ru - aunc的ECL信号增强机制。Hg2+的相互作用蚀刻了Ru - auncs的笼状结构，加速了传感电极周围更多的Ru(bpy)32+的释放。此外，Ru-AuNCs表面形成了Au-Hg合金结构，这也改善了ECL信号。这种靶诱导原位传感材料表面重构策略将为ECL POCT传感器的构建提供更好的设计理念。

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产品信息

阿拉丁

4-Morpholineethanesulfonic acid

阿拉丁

Tris (2,2′-bipyridyl) ruthenium dichloride (II) hexahydrate

来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.