{"title":"Controlling the occurrence sequence of reaction modules through biochemical relaxation oscillators","authors":"Xiaopeng Shi , Chuanhou Gao , Denis Dochain","doi":"10.1016/j.automatica.2025.112261","DOIUrl":null,"url":null,"abstract":"<div><div>Embedding sequential computations in biochemical environments is challenging because the computations are carried out through chemical reactions, which are inherently disordered. In this paper we apply modular design to specific calculations through chemical reactions and provide a design scheme of biochemical oscillator models in order to generate periodical species for the order regulation of these reaction modules. We take the case of arbitrary multi-module regulation into consideration, analyze the main errors in the regulation process under <em>mass-action kinetics</em> and illustrate our design scheme under existing synthetic biochemical oscillator models.</div></div>","PeriodicalId":55413,"journal":{"name":"Automatica","volume":"176 ","pages":"Article 112261"},"PeriodicalIF":4.8000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Automatica","FirstCategoryId":"94","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0005109825001530","RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AUTOMATION & CONTROL SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Embedding sequential computations in biochemical environments is challenging because the computations are carried out through chemical reactions, which are inherently disordered. In this paper we apply modular design to specific calculations through chemical reactions and provide a design scheme of biochemical oscillator models in order to generate periodical species for the order regulation of these reaction modules. We take the case of arbitrary multi-module regulation into consideration, analyze the main errors in the regulation process under mass-action kinetics and illustrate our design scheme under existing synthetic biochemical oscillator models.
期刊介绍：
Automatica is a leading archival publication in the field of systems and control. The field encompasses today a broad set of areas and topics, and is thriving not only within itself but also in terms of its impact on other fields, such as communications, computers, biology, energy and economics. Since its inception in 1963, Automatica has kept abreast with the evolution of the field over the years, and has emerged as a leading publication driving the trends in the field.
After being founded in 1963, Automatica became a journal of the International Federation of Automatic Control (IFAC) in 1969. It features a characteristic blend of theoretical and applied papers of archival, lasting value, reporting cutting edge research results by authors across the globe. It features articles in distinct categories, including regular, brief and survey papers, technical communiqués, correspondence items, as well as reviews on published books of interest to the readership. It occasionally publishes special issues on emerging new topics or established mature topics of interest to a broad audience.
Automatica solicits original high-quality contributions in all the categories listed above, and in all areas of systems and control interpreted in a broad sense and evolving constantly. They may be submitted directly to a subject editor or to the Editor-in-Chief if not sure about the subject area. Editorial procedures in place assure careful, fair, and prompt handling of all submitted articles. Accepted papers appear in the journal in the shortest time feasible given production time constraints.
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