Association of e-cigarette use, psychological distress, and substance use: Insights from the All of Us Research Program

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL Addictive behaviors Pub Date : 2025-03-19 DOI:10.1016/j.addbeh.2025.108322

John Erhabor , Zhiqi Yao , Erfan Tasdighi , Omar El Shahawy , Emelia J. Benjamin , Aruni Bhatnagar , Michael J. Blaha

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Abstract

Background/Aim

Understanding the social context of e-cigarette use in the United States (U.S.) remains a high priority.

Methods

In this cross-sectional study, we included 68,356 adults aged ≥18 from the All of Us research program’s COVID-19 Participant Experience (COPE) survey who had complete e-cigarette use information. Multivariable-adjusted logistic regression was used to examine the association between e-cigarette use (current, former, and never), psychological distress, and substance use.

Results

In the sample, most were male (66.3 %) and white (81.9 %), with 2.9 % reporting former and 2.3 % current e-cigarette use. Individuals reporting former or current e-cigarette use had a higher prevalence of psychological distress (e.g., depressive symptoms: never 49.6 %, former 70.2 %, current 73.4 %) and substance use (e.g., cannabis: never 9.8 %, former 37.0 %, current 42.6 %) than never e-cigarette use. Compared with never use, current e-cigarette use was associated with higher odds of depressive symptoms (aOR, 1.53 95 % CI: 1.34–1.74), anxiety (aOR1.36, 1.19–1.57), suicidal ideation (aOR1.55, 1.32–1.82), stress (aOR1.41, 1.24–1.59), as well as, cannabis (aOR 2.72, 2.40–3.08), opioids (aOR1.92, 1.56–2.36), stimulants (aOR2.33, 1.91–2.83), sedatives (aOR1.68, 1.43–1.98), hallucinogens (aOR1.94, 1.28–2.90), and cocaine use (aOR1.85, 1.21–2.79). Similar significant associations were observed in former, occasional and daily e-cigarette use, with comparable estimates across sexes.

Conclusion

In this unique well-powered All of US dataset, there was a significant cross-sectional association between e-cigarette use, psychological distress, and substance use, indicating that the social context of e-cigarette use is closely linked to key well-being domains. These data provide high precision estimates that can be used to inform interventions aimed at creating awareness of e-cigarette use correlates.

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背景/目的了解美国使用电子烟的社会背景仍是当务之急。方法在这项横断面研究中，我们从 "我们所有人 "研究项目的 COVID-19 参与者体验（COPE）调查中纳入了 68,356 名年龄≥18 岁、拥有完整电子烟使用信息的成年人。采用多变量调整逻辑回归法研究了使用电子烟（目前、曾经和从未使用过）、心理困扰和药物使用之间的关联。结果在样本中，大多数为男性（66.3%）和白人（81.9%），其中 2.9% 报告曾经使用过电子烟，2.3% 报告目前使用过电子烟。与从未使用电子烟相比，曾经或目前使用电子烟的人有更高的心理困扰（如抑郁症状：从未使用过的占 49.6%，曾经使用过的占 70.2%，目前使用过的占 73.4%）和药物使用（如大麻：从未使用过的占 9.8%，曾经使用过的占 37.0%，目前使用过的占 42.6%）。与从未使用电子烟相比，目前使用电子烟与抑郁症状（aOR，1.53 95 % CI：1.34-1.74）、焦虑（aOR1.36，1.19-1.57）、自杀倾向（aOR1.55，1.32-1.82）、压力（aOR1.41，1.此外，大麻（aOR2.72，2.40-3.08）、阿片类药物（aOR1.92，1.56-2.36）、兴奋剂（aOR2.33，1.91-2.83）、镇静剂（aOR1.68，1.43-1.98）、致幻剂（aOR1.94，1.28-2.90）和可卡因的使用（aOR1.85，1.21-2.79）也有类似的显著关联。）在曾经、偶尔和每天使用电子烟的人群中也观察到了类似的显着关联，不同性别的估计值具有可比性。结论在这个独特的、具有良好效应的全美数据集中，电子烟使用、心理困扰和药物使用之间存在显着的横断面关联，表明电子烟使用的社会背景与关键的福祉领域密切相关。这些数据提供了高精度的估计值，可为旨在提高人们对电子烟使用相关性认识的干预措施提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Addictive behaviors 医学-药物滥用

CiteScore

8.40

自引率

4.50%

发文量

283

审稿时长

46 days

期刊介绍： Addictive Behaviors is an international peer-reviewed journal publishing high quality human research on addictive behaviors and disorders since 1975. The journal accepts submissions of full-length papers and short communications on substance-related addictions such as the abuse of alcohol, drugs and nicotine, and behavioral addictions involving gambling and technology. We primarily publish behavioral and psychosocial research but our articles span the fields of psychology, sociology, psychiatry, epidemiology, social policy, medicine, pharmacology and neuroscience. While theoretical orientations are diverse, the emphasis of the journal is primarily empirical. That is, sound experimental design combined with valid, reliable assessment and evaluation procedures are a requisite for acceptance. However, innovative and empirically oriented case studies that might encourage new lines of inquiry are accepted as well. Studies that clearly contribute to current knowledge of etiology, prevention, social policy or treatment are given priority. Scholarly commentaries on topical issues, systematic reviews, and mini reviews are encouraged. We especially welcome multimedia papers that incorporate video or audio components to better display methodology or findings. Studies can also be submitted to Addictive Behaviors? companion title, the open access journal Addictive Behaviors Reports, which has a particular interest in ''non-traditional'', innovative and empirically-oriented research such as negative/null data papers, replication studies, case reports on novel treatments, and cross-cultural research.