{"title":"A model of tubulin removal and exchange caused by kinesin motor walking on microtubule lattices","authors":"Ping Xie","doi":"10.1016/j.jtbi.2025.112088","DOIUrl":null,"url":null,"abstract":"<div><div>The kinesin motor walking on microtubule lattices can cause disassembly of GDP-tubulins, generating defects, and repair the defects by incorporating GTP-tubulins. To explore the underlying mechanism, a model is proposed here. On the basis of the model, the dynamics of the defect generation, defect repair and tubulin exchange induced by the kinesin motor is studied theoretically. The theoretical results explain well the available experimental data. Moreover, predicted results are provided.</div></div>","PeriodicalId":54763,"journal":{"name":"Journal of Theoretical Biology","volume":"605 ","pages":"Article 112088"},"PeriodicalIF":1.9000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Theoretical Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022519325000542","RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The kinesin motor walking on microtubule lattices can cause disassembly of GDP-tubulins, generating defects, and repair the defects by incorporating GTP-tubulins. To explore the underlying mechanism, a model is proposed here. On the basis of the model, the dynamics of the defect generation, defect repair and tubulin exchange induced by the kinesin motor is studied theoretically. The theoretical results explain well the available experimental data. Moreover, predicted results are provided.
期刊介绍：
The Journal of Theoretical Biology is the leading forum for theoretical perspectives that give insight into biological processes. It covers a very wide range of topics and is of interest to biologists in many areas of research, including:
• Brain and Neuroscience
• Cancer Growth and Treatment
• Cell Biology
• Developmental Biology
• Ecology
• Evolution
• Immunology,
• Infectious and non-infectious Diseases,
• Mathematical, Computational, Biophysical and Statistical Modeling
• Microbiology, Molecular Biology, and Biochemistry
• Networks and Complex Systems
• Physiology
• Pharmacodynamics
• Animal Behavior and Game Theory
Acceptable papers are those that bear significant importance on the biology per se being presented, and not on the mathematical analysis. Papers that include some data or experimental material bearing on theory will be considered, including those that contain comparative study, statistical data analysis, mathematical proof, computer simulations, experiments, field observations, or even philosophical arguments, which are all methods to support or reject theoretical ideas. However, there should be a concerted effort to make papers intelligible to biologists in the chosen field.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
