Lymphocyte Subpopulations in the Healthy Human Lacrimal Gland and Their Variations With Age and Sex, Systematic Review 1960–2023

IF 3.1 4区医学 Q3 IMMUNOLOGY Immunity, Inflammation and Disease Pub Date : 2025-03-19 DOI:10.1002/iid3.70167

Claudia M. Trujillo-Vargas, Luisa María Rendón-Macías, Ronald Yamil Paredes Guerrero, Cinta S. de Paiva, Jaiberth Antonio Cardona-Arias

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Abstract

Background

Immunosenescence has been associated with an imbalance in the lacrimal functional unit and histopathological changes in exocrine glands, especially in women.

Objective

To define the main lymphocyte subpopulations in the human lacrimal gland and their variations with age and sex, according to scientific articles published between 1960 and 2023.

Methods

A systematic review was performed on PubMed, ScienceDirect, and Google Scholar. The PRISMA 2020 guidelines were applied for the search and selection of studies.

The methodological quality was evaluated with the STROBE guidelines. A meta-analysis of three selected articles dichotomizing lymphocytic infiltrates according to age group was also performed.

Results

We selected 20 observational studies, including 774 healthy individuals (722 cadavers). The articles evaluated the lymphocyte infiltration with hematoxylin and eosin staining, immunohistochemistry and immunofluorescence. There was high variability in the criteria to define the apparently human lacrimal and to quantify the lymphocytic infiltration. There was an underrepresentation of individuals younger than 40 years (12.6%), and female sex (38.9%). Three articles reported an association of age and sex with lymphocytic infiltration in the healthy lacrimal gland, while two articles did not. Plasma cells were the most abundant lymphocyte subpopulation in the healthy lacrimal gland, including IgA-containing plasma cells. B cells were reported to be very scarce in the LG in two articles. In the meta-analysis of three selected articles, no statistical difference in lymphocytic infiltration was found between individuals younger and older than 60.

Conclusion

There is the need of further observational studies, better defining the study design, with similar representation across sex and ages to ascertain what are the changes of lymphocytic composition in the lacrimal gland related to age and sex. Further studies are also needed to assess the dynamics of lymphocytic populations in a more detailed manner using cutting-edge methodologies such as single-cell sequencing or transcriptomics.

Trial Registration

PROSPERO 2023 CRD42023435653 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023435653.

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology