Kaihan Su, Xiaoyu Wang, ShiYin Zhang, Jiantong Wu, Yuqi Chen, Lianjun Yin, Haunan Li, Jingui Wang
{"title":"Efficacy of acupuncture for stroke-associated pneumonia: a systematic review and meta-analysis.","authors":"Kaihan Su, Xiaoyu Wang, ShiYin Zhang, Jiantong Wu, Yuqi Chen, Lianjun Yin, Haunan Li, Jingui Wang","doi":"10.3389/fmed.2025.1440121","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to systematically evaluate the efficacy of acupuncture on stroke-associated pneumonia (SAP).</p><p><strong>Methods: </strong>English and Chinese databases were searched from their inception until 15 March 2024 to collect randomized controlled trials (RCTs). The risk of bias was assessed using Cochrane collaboration tools. RevMan 5.4.0 software was used to analyze the included studies, and the Grades of Recommendations, Assessment, Development, and Evaluation (GRADE) assessment was used to evaluate the quality of the study outcomes.</p><p><strong>Results: </strong>16 studies involving 1,125 patients were included in this meta-analysis. Compared with the control group, the results showed that acupuncture significantly improved the effective rate [RR = 1.20, 95% CI (1.13, 1.27), <i>P</i> < 0.00001] and reduced the level of white blood cells (WBC) [MD = -6.52, 95% CI (-8.31, -4.73), <i>P</i> < 0.00001], C reactive protein (CRP) [MD = -6.50, 95% CI (-9.97, -3.03), <i>P</i> = 0.0002], neutrophil percentage (Neu%) [MD = -6.66, 95% CI (-8.96, -4.36), <i>P</i> < 0.00001], and procalcitonin (PCT) [MD = -0.81, 95% CI (-1.21, -0.40), <i>P</i> < 0.0001]. Additionally, acupuncture therapy shortened the duration of coughing [MD = -3.22, 95% CI (-4.73, -1.72), <i>P</i> < 0.0001], duration until disappearance of rales [MD = -3.99, 95% CI (-6.44, -1.54), <i>P</i> = 0.001], and duration of antibiotic use [MD = -4.51, 95% CI (-5.46, -3.57), <i>P</i> < 0.00001]. It also reduced the clinical pulmonary infection score (CPIS) [MD = -1.71, 95% CI (-2.71, -0.71), <i>P</i> = 0.0008] and National Institute of Health Stroke Scale (NIHSS) [MD = -3.93, 95% CI (-5.78, -2.09), <i>P</i> < 0.00001]. Moreover, acupuncture therapy increased the forced vital capacity (FVC) [MD = 0.46, 95% CI (0.02, 0.89), <i>P</i> = 0.04] and Forced Expiratory Volume in One Second (FEV<sub>1</sub>) [MD = 0.49, 95% CI (0.14, 0.84), <i>P</i> = 0.006].</p><p><strong>Conclusion: </strong>This study found that acupuncture has a positive effect in treating SAP. However, owing to the low-quality evidence, more rigorous studies are needed in the coming years to confirm these findings.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023462846, identifier CRD42023462846.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1440121"},"PeriodicalIF":3.1000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911211/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fmed.2025.1440121","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: This study aims to systematically evaluate the efficacy of acupuncture on stroke-associated pneumonia (SAP).
Methods: English and Chinese databases were searched from their inception until 15 March 2024 to collect randomized controlled trials (RCTs). The risk of bias was assessed using Cochrane collaboration tools. RevMan 5.4.0 software was used to analyze the included studies, and the Grades of Recommendations, Assessment, Development, and Evaluation (GRADE) assessment was used to evaluate the quality of the study outcomes.
Results: 16 studies involving 1,125 patients were included in this meta-analysis. Compared with the control group, the results showed that acupuncture significantly improved the effective rate [RR = 1.20, 95% CI (1.13, 1.27), P < 0.00001] and reduced the level of white blood cells (WBC) [MD = -6.52, 95% CI (-8.31, -4.73), P < 0.00001], C reactive protein (CRP) [MD = -6.50, 95% CI (-9.97, -3.03), P = 0.0002], neutrophil percentage (Neu%) [MD = -6.66, 95% CI (-8.96, -4.36), P < 0.00001], and procalcitonin (PCT) [MD = -0.81, 95% CI (-1.21, -0.40), P < 0.0001]. Additionally, acupuncture therapy shortened the duration of coughing [MD = -3.22, 95% CI (-4.73, -1.72), P < 0.0001], duration until disappearance of rales [MD = -3.99, 95% CI (-6.44, -1.54), P = 0.001], and duration of antibiotic use [MD = -4.51, 95% CI (-5.46, -3.57), P < 0.00001]. It also reduced the clinical pulmonary infection score (CPIS) [MD = -1.71, 95% CI (-2.71, -0.71), P = 0.0008] and National Institute of Health Stroke Scale (NIHSS) [MD = -3.93, 95% CI (-5.78, -2.09), P < 0.00001]. Moreover, acupuncture therapy increased the forced vital capacity (FVC) [MD = 0.46, 95% CI (0.02, 0.89), P = 0.04] and Forced Expiratory Volume in One Second (FEV1) [MD = 0.49, 95% CI (0.14, 0.84), P = 0.006].
Conclusion: This study found that acupuncture has a positive effect in treating SAP. However, owing to the low-quality evidence, more rigorous studies are needed in the coming years to confirm these findings.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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