{"title":"EFFECTS OF COMBINED HORMONAL CONTRACEPTIVES (CHC) ON BONE HEALTH IN ADOLESCENT GIRLS - A SYSTEMATIC REVIEW.","authors":"Leek Mei Lim, Wogud Ben Said, Pallavi Latthe","doi":"10.1016/j.jpag.2025.03.004","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To summarize the effects of combined hormonal contraceptives (CHC) on bone health in adolescent girls.</p><p><strong>Design: </strong>A systematic search was performed using the following databases: Medline, EMBASE, CINAHL and Cochrane Library clinical trials register, from inception to July 2024.</p><p><strong>Eligibility: </strong>Intervention and cohort studies that assessed the use of CHC on bone health in adolescent girls aged 10-19years old were included.</p><p><strong>Data synthesis: </strong>Four randomized control trials and eight observational studies (n =2689) were included.</p><p><strong>Conclusion: </strong>Current evidence indicates that the use of CHC in post-menarchal adolescent girls reduce bone accrual compared to non-users. The negative impact on bone accrual is likely related to the estrogen dose in the CHC preparation, the regimen used and the duration of use.</p><p><strong>Prospero registration number: </strong>PROSPERO CRD 42024574905 on 31 July 2024.</p>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pediatric and adolescent gynecology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jpag.2025.03.004","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: To summarize the effects of combined hormonal contraceptives (CHC) on bone health in adolescent girls.
Design: A systematic search was performed using the following databases: Medline, EMBASE, CINAHL and Cochrane Library clinical trials register, from inception to July 2024.
Eligibility: Intervention and cohort studies that assessed the use of CHC on bone health in adolescent girls aged 10-19years old were included.
Data synthesis: Four randomized control trials and eight observational studies (n =2689) were included.
Conclusion: Current evidence indicates that the use of CHC in post-menarchal adolescent girls reduce bone accrual compared to non-users. The negative impact on bone accrual is likely related to the estrogen dose in the CHC preparation, the regimen used and the duration of use.
Prospero registration number: PROSPERO CRD 42024574905 on 31 July 2024.
期刊介绍：
Journal of Pediatric and Adolescent Gynecology includes all aspects of clinical and basic science research in pediatric and adolescent gynecology. The Journal draws on expertise from a variety of disciplines including pediatrics, obstetrics and gynecology, reproduction and gynecology, reproductive and pediatric endocrinology, genetics, and molecular biology.
The Journal of Pediatric and Adolescent Gynecology features original studies, review articles, book and literature reviews, letters to the editor, and communications in brief. It is an essential resource for the libraries of OB/GYN specialists, as well as pediatricians and primary care physicians.
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