Therapeutic implication of oxidative stress-induced growth inhibitor 1 (OSGIN1) in cancer

IF 7.3 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Oncogene Pub Date : 2025-03-17 DOI:10.1038/s41388-025-03349-5

Dong Joon Kim, Yong Weon Yi, Zigang Dong, Yeon-Sun Seong

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Abstract

Oxidative stress is an imbalance of free radicals and antioxidants in redox signaling that regulate various pathogenesis and cellular functions. Although advances in technology provide further knowledge for biomarkers and potential therapeutic targets of oxidative stress, it is still needed to validate them to apply in clinical relevance, diagnostics, and therapeutics. With these backgrounds, a clinical understanding of biomarkers and molecular mechanisms has been emphasized. In this review, we describe oxidative stress-induced growth inhibitor 1 (OSGIN1), an oxidative stress response protein. Previous findings have provided evidence implicating the function of oxidative stress-dependent and -independent response in numerous chronic diseases and cancers. However, the functions and roles of OSGIN1 in tumorigenesis have not been appreciated yet. We highlight the cellular processes and functions dependent on the expression of OSGIN1 isoforms as well as the regulation of its expression by various cellular signaling pathways, especially in cancer. This review will provide an overview of the clinical significance and molecular mechanisms of OSGIN1.

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氧化应激诱导生长抑制剂1 （OSGIN1）在癌症中的治疗意义。

氧化应激是氧化还原信号中自由基和抗氧化剂的失衡，调节各种发病机制和细胞功能。尽管技术的进步为氧化应激的生物标志物和潜在治疗靶点提供了进一步的知识，但仍需要验证它们在临床相关性、诊断和治疗中的应用。在这些背景下，强调了对生物标志物和分子机制的临床理解。在这篇综述中，我们描述了氧化应激诱导生长抑制剂1 (OSGIN1)，一种氧化应激反应蛋白。先前的研究结果提供了证据，表明氧化应激依赖性和非依赖性反应在许多慢性疾病和癌症中的作用。然而，OSGIN1在肿瘤发生中的功能和作用尚不清楚。我们强调了依赖于OSGIN1亚型表达的细胞过程和功能，以及各种细胞信号通路对其表达的调节，特别是在癌症中。本文就OSGIN1的临床意义及分子机制作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncogene 医学-生化与分子生物学

CiteScore

15.30

自引率

1.20%

发文量

404

审稿时长

1 months

期刊介绍： Oncogene is dedicated to advancing our understanding of cancer processes through the publication of exceptional research. The journal seeks to disseminate work that challenges conventional theories and contributes to establishing new paradigms in the etio-pathogenesis, diagnosis, treatment, or prevention of cancers. Emphasis is placed on research shedding light on processes driving metastatic spread and providing crucial insights into cancer biology beyond existing knowledge. Areas covered include the cellular and molecular biology of cancer, resistance to cancer therapies, and the development of improved approaches to enhance survival. Oncogene spans the spectrum of cancer biology, from fundamental and theoretical work to translational, applied, and clinical research, including early and late Phase clinical trials, particularly those with biologic and translational endpoints.