Recent advances and prospects of nanoparticle-based drug delivery for diabetic ocular complications.

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Theranostics Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI:10.7150/thno.108691
Siqi Wang, Hongyu Yang, Jiaying Zheng, Aiyang Tong, Sen Mu, Dongkai Wang, Ming Zhao, Ji Li
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Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder that significantly affects various organ systems. The systemic effects of DM lead to numerous complications, with ocular manifestations being of particular concern due to their severity and impact on quality of life. Hyperglycemia-induced ocular damage often results in a range of lesions, including diabetic retinopathy (DR), keratopathy, cataracts, and glaucoma. These conditions impose considerable physical discomfort on patients and place a substantial economic burden on healthcare systems. The advent of nanotechnology has facilitated the development of innovative therapeutic strategies for managing diabetic ocular complications. This review highlights several common ocular complications associated with DM, focusing on their pathogenesis and treatment strategies. Emphasis is placed on the innovative applications and potential of nanotechnology in treating diabetic ocular complications.

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纳米颗粒给药治疗糖尿病眼部并发症的研究进展与展望。
糖尿病(DM)是一种慢性代谢性疾病,严重影响各器官系统。糖尿病的全身性影响导致许多并发症,由于其严重程度和对生活质量的影响,眼部表现尤其值得关注。高血糖引起的眼部损伤通常会导致一系列病变,包括糖尿病视网膜病变(DR)、角膜病变、白内障和青光眼。这些疾病给患者带来了相当大的身体不适,并给医疗保健系统带来了沉重的经济负担。纳米技术的出现促进了管理糖尿病眼部并发症的创新治疗策略的发展。本文综述了几种常见的与糖尿病相关的眼部并发症,重点讨论了它们的发病机制和治疗策略。重点是纳米技术在治疗糖尿病眼部并发症方面的创新应用和潜力。
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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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