Unraveling the metabolic‒epigenetic nexus: a new frontier in cardiovascular disease treatment.

IF 9.6 1区生物学 Q1 CELL BIOLOGY Cell Death & Disease Pub Date : 2025-03-18 DOI:10.1038/s41419-025-07525-z

Jun Ouyang, Deping Wu, Yumei Gan, Yuming Tang, Hui Wang, Jiangnan Huang

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Abstract

Cardiovascular diseases are the leading causes of death worldwide. However, there are still shortcomings in the currently employed treatment methods for these diseases. Therefore, exploring the molecular mechanisms underlying cardiovascular diseases is an important avenue for developing new treatment strategies. Previous studies have confirmed that metabolic and epigenetic alterations are often involved in cardiovascular diseases across patients. Moreover, metabolic and epigenetic factors interact with each other and affect the progression of cardiovascular diseases in a coordinated manner. Lactylation is a novel posttranslational modification (PTM) that links metabolism with epigenetics and affects disease progression. Therefore, analyzing the crosstalk between cellular metabolic and epigenetic factors in cardiovascular diseases is expected to provide insights for the development of new treatment strategies. The purpose of this review is to describe the relationship between metabolic and epigenetic factors in heart development and cardiovascular diseases such as heart failure, myocardial infarction, and atherosclerosis, with a focus on acylation and methylation, and to propose potential therapeutic measures.

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揭示代谢-表观遗传关系：心血管疾病治疗的新前沿。

心血管疾病是全世界死亡的主要原因。然而，目前对这些疾病的治疗方法还存在不足。因此，探索心血管疾病的分子机制是开发新的治疗策略的重要途径。先前的研究已经证实，代谢和表观遗传改变通常与患者的心血管疾病有关。此外，代谢和表观遗传因素相互作用，协调影响心血管疾病的进展。乳酸酰化是一种新的翻译后修饰（PTM），将代谢与表观遗传学联系起来并影响疾病进展。因此，分析心血管疾病中细胞代谢和表观遗传因素之间的串扰，有望为开发新的治疗策略提供见解。本综述的目的是描述心脏发育和心血管疾病（如心力衰竭、心肌梗死和动脉粥样硬化）中代谢和表观遗传因素之间的关系，重点关注酰化和甲基化，并提出潜在的治疗措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death & Disease CELL BIOLOGY-

CiteScore

15.10

自引率

2.20%

发文量

935

审稿时长

2 months

期刊介绍： Brought to readers by the editorial team of Cell Death & Differentiation, Cell Death & Disease is an online peer-reviewed journal specializing in translational cell death research. It covers a wide range of topics in experimental and internal medicine, including cancer, immunity, neuroscience, and now cancer metabolism. Cell Death & Disease seeks to encompass the breadth of translational implications of cell death, and topics of particular concentration will include, but are not limited to, the following: Experimental medicine Cancer Immunity Internal medicine Neuroscience Cancer metabolism