Anti-inflammatory and Gastroprotective Effects of the Chamaerops humilis L. (DOUM) Fruit Aqueous Extract in Experimental Models of Edema and Gastric Ulcer

Abstract

Chronic inflammation can lead to various diseases, including gastric ulcers, highlighting the need for effective therapeutic strategies. The traditional use of Chamaerops humilis in Moroccan folk medicine for treating gastrointestinal disorders underscores its potential as a valuable natural remedy. This study rigorously evaluates the anti-inflammatory and gastroprotective effects of the aqueous extract of C. humilis (AECH) through a series of well-established animal models, including carrageenan-induced paw edema, xylene-induced ear edema, and ethanol/hydrochloric acid (EtOH/HCL)-induced gastric ulcers. The results reveal that AECH significantly reduces inflammation and ulcer severity in a dose-dependent manner, demonstrating potent efficacy in decreasing paw and ear edema while markedly mitigating ulceration induced by EtOH/HCL exposure. Notably, AECH achieved up to 100% inhibition of ulcer lesions at higher doses. These findings not only validate the traditional applications of C. humilis but also highlight its promising role as a natural therapeutic agent for managing inflammatory conditions and gastric ulcers.